Etiology And Clinical Retrospective Analysis Of1627Children With Liver Disfuction

ObjectiveTo further investigate the distribution of the age, gender, the degreeof ALT level, the etiology and clinical manifestations in children withliver dysfunction. And then to provide a basis for the diagnosis andtreatment of liver dysfunction of children.MethodsThe data of hospitalized children with liver dysfunction aged1months-16years old in children’s hospital of Chongqing MedicalUniversity from April to September in2011was statistical analyzedretrospectively. The data was counted using statistical analysis ofChi-Square Test and Rank and inspection.Results1. There were1627children complicated with liver dysfunction,including980boys and647girls. There was significant differencebetween male and female. However, we did not find any significantdifference between different ages about the rate of the gender.2. In this study, the number of1-5months infants was over than thatof any other group; nevertheless, the number of13-16years children wasless than that of other groups. The incidence rate among1-6months,6months-1year old,1-3years old,3-6years old,6-13years old and13-16years was36.3%,15.9%,15.1%,14.1%,16.0%and2.7% respectively.3. We divided ALT into five different levels:50<ALT <100U/L，100≤ALT<200U/L，200≤ALT<400U/L，400≤ALT<1000U/L andALT≥1000U/L, the corresponding proportion was51.2%,25.3%,13.7%,6.8%and3.1%，Which implied that children with liver damage mainlyhave mild dysfunction, and the proportion was negativelycorrelated with the degree of liver damage. Moreover,1-5months infantshad lower levels of ALT than that in toddlers, preschool and school-agechildren,6-12months infants had lower levels of ALT than thatin preschool and school-age children. Meanwhile, toddlers andschool-age children had lower levels of ALT than that in preschoolchildren.4. In this study, there were709cases with infectious disease,471cases with noninfectious disease, and447cases which were not identifiedby a clear cause.Infectious disease was more common in infants, and non-infectivedisease was more common in children who were older than1year, in thecases with identified causes. In infectious disease, virus infection wasmost frequent; and in on-infective disease, abnormal liver and biliarystructure、CTD、injury and drugs or toxin were the main cause in1-5months infants、6months-2years、3-5years and6-16years oldchildren respectively.5. The clinical manifestations and the proportion of total cases asfollows: There were7.8%cases had jaundice,29.0%cases hadhepatomegaly,12.5%cases had splenomegaly,11.0%cases had swollenlymph nodes,8.6%cases had rash and3.1%cases had hemorrhagetendency. Jaundice incidence in1-5months was higher than that in6months-12years old children. The infantile group had lower incidence of splenomegaly than that in preschool and school-age children. There wasno significantly difference of the incidence of hepatomegaly in differentage periods.Conclusion1. Boys are more than girls in children with abnormal ALT liverfunction. There is no significantly difference between gender in differentage.2. In the total cases with ALT abnormality of liver dysfunction, thehighest frequency is in1-5months group, and the lowest frequency is in13-16years group.3. The proportion of children with liver dysfunction is negativecorrelation with damage degree.4. Infectious diseases is the main causes of the children with liverdysfunction, in which the virus infection is most common cause of ALTabnormality. In non-infectious disease, connective tissue disease was themost common cause.5. A small part of the children with liver dysfunction have specificmanifestations.