Bitter Dish To Patients With Cerebral Infarction Injection Serum HsCRP、IL-18Affect Clinical Research

Objective:Clinical research on effects of Bitter dish injection liquid to serum hsCRP、IL-18of patients with acute cerebral infarction.Method:Set appropriate into and exclusion standard, about the chosen by the method of case randomized,60patients with acute cerebral infarction patients were randomly divided into two groups.30cases of the comparison group was treated with methods of anti-platelet aggregation and improve brain edema and cerebral circulation, removing oxygen free radicals, preventing calcium overload and so on, the treatment group in this foundation of30cases of combined with bitter dish injection for treatment,14days as one period of treatment, Changes of the serum hsCRP, IL-18content in the two groups were tested before and after treatment respectively by ELISA method., at the same time to assess statistical analysis were carried out on neural function scores, daily life activities Barthel index, TCM syndrome score and outcome before and after treatment.Results:(1) The neurobehavioral scores, before and after treatment, in the two groups are different.(P<0.01);(2) Barthel index before and after treatment, of the two groups neurobehavioral scores significant Have significant difference (P<0.01);(3) TCM syndrome score and outcome, before and after treatment, have also significant difference (P <0.05),(4) After treatment, both the serum hsCRP、IL-18content of the two groups decreased (P<0.05), but the decrease of that in the treatment group is larger (P<0.01);(5)Before and after treatment hsCRP serum, IL-18in a significant relationship (P<0.01).Conclusion:(1) Bitter dish injection in the treatment of patients with acute cerebral infarction, can promote recovery of neural function, improve the Barthel index of daily life and curative effect of TCM syndrome type, so as to improve survival quality of patients with acute cerebral infarction.(2) Bitter dish injection can reduce serum hsCRP, IL-18, and one of the treatment effect of them may can reduce serum inflammation factors through hsCRP、IL-18to brain damage,the protection of brain tissue.