Bitter Dish Injection In Treatment Of Acute Cerebral Infarction Adaptation Syndrome Research

Objective:to evaluate the curative effect and security of Kudiezi injection in the treatment of acute cerebral infarction, and find the Chinese traditional medicine indication type through the retrospective research of the use of Kudiezi injection in the treatment of acute cerebral infarctionMethod:First,do some literature research in Kudiezi injection to the treatment of acute cerebral infarction,then using the Cochrane system evaluation to retrieve CNKI,CBM,VIP to screen all randomized controlled trials (RCT) which use Kudiezi injection in the treatment of acute cerebral infarction,and then analysis the trials with RevMan statistical software. The third part is the clinical research, and the patients in the research are hospitalized patients with cerebral infarction from January2009to December2012in our hospital, all patients uses Kudiezi injection to treat acute cerebral infarction.Then analysis the curative effect of Kudiezi injection among different types before and after the research with t test of SPSS20.0statistical software.Result:First,208articles were found, and ultimately26articles were internalized. The case fatality ratio of Meta analysis shows that there is no difference between Kudiezi injection group and western medicine group,P=0.45(RR:0.63,95%:CI [0.19,2.09] P=0.86, I2=0%); The Meta analysis about the score of ability of daily life shows that after14days there is also no difference between Kudiezi injection group and control group on the score of ability of daily life,P=1(RR:0.04,95%CI:[-15.46,15.55], P<0.00001, I2=98%);The meta analysis of nerve function defect score shows that there is no difference between Kudiezi injection group and the control group after14days on the score of nerve function defect,P=0.004(RR:-2.23,95%CI:[-3.74,-0.71], P<0.00001, I2=96%), but after14days, the score of nerve function defect of Kudiezi injection group is different from other traditional Chinese medicine injection group,P<0.00001(RR:-4.51,95%CI:[-6.06,-2.97], P=0.04, I2=58%). Retrospective clinical study results show that before and after treatment BI integral and traditional Chinese medicine zhenghou integral of the treatment group are different on hot syndrome, phlegm syndrome, blood stasis syndrome respectively, P0.05. Before and after treatment BI integral and traditional Chinese medicine zhenghou integral of the control group are also different on hot syndrome,phlegm syndrome, blood stasis syndrome respectively, P<0.05.The curative effect of hot syndrome and blood stasis syndrome between the treatment group and the control group are different, P<0.05,and the same to the phlegm syndrome. Compare the effective rate of the three type in the treatment group respectively,and the result shows that differences between hot syndrome and phlegm syndrome is statiscally meaningless, P>0.05.The curative effect between Hot syndrome and blood stasis syndrome is different. P<0.05. The curative effect between phlegm syndrome and blood stasis syndrome is different too, P<0.05.Conclusion:Kudiezi injection is effective for nerve function defect of acute cerebral infarction, and at the same time, with good safety. Kudiezi injection is effective for the hot syndrome, phlegm syndrome, blood stasis syndrome of acute cerebral infarction. And the curative effect to the hot syndrome and the phlegm syndrome are better than that to the blood stasis syndrome. At last, curative effect of the phlegm syndrome in the treatment group is better than that of the control group.