Prevalence And Risk Factors Of Hyperuricemia For Civil Servants In Zhengzhou

The prevalence of hyperuricemia (HUA) in China is increasing rapidly, particularly in the males, which is due to the rapid development of society, the changes of dietary structure and other influencing factors. Hyperuricemia increases the risk of hypertension, diabetes mellitus (DM), dyslipidemia, and coronary heart disease.ObjectiveThe purpose of this study is to learn the preverlance rate and influencing factors of HUA and the risk factors clustering status in the civil servants aged18-97years in Zhengzhou City and to provide a scientific basis for prevention and treatment of HUA for the civil servants population.MethodsThere were4721representative civil servant participants to be investigated in a hospital of Henan from January to August in2010who aged18-97years in Zhengzhou City. Case-control and cross-sectional study were used for this investagation.Results1. A total of4721individuals were investigated. The males were3213(68.06%), and the females were1508(31.94%), the average age was44.86＋12.85(mean±SD) years old.2. The serum uric acid was278.3±64.5(mean±SD) μmoI/L for the study participants. The levels of SUA for males were higher than that for females (t=15.52, P＜0.001), It was increased with age in the women (F=3.33, P<0.001), but that change in men is not significantly(F=0.12, P=0.980).3. The crude prevalence rate of HUA was5.57%, and the age-standardized rate was5.32%by the fifth census data of2000in China. The prevalence of HUA for the males (6.44%) was significantly higher than that for the females (3.71%)(χ2=9.976, P<0.001). The prevalence rate of HUA was increased with the age in women (Z=14.764, P<0.001).4. Logistic regression analysis indicated that the risk of HUA were increased by the following factors significantly:hypertension (OR=2.12,95%CI:1.84～2.45), hyperglycemia (OR=1.21,95%CI:1.12～1.31), hypertriglyceridemia (OR=2.04,95%CI:1.95～2.68), hypercholesterolemia (OR=2.60,95%CI:2.25～3.01),low high-density lipoprotein hematic disease (OR=1.36,95%CI:1.21～1.53) and high low density lipoprotein hematic disease (OR=1.23,95%CI:1.08～1.39).5. Compareing with the participants not having any risk factors, the OR (95%CI) of those which having1,2and3risk factors to develop HUA were1.38(1.16～1.54),2.01(1.71～2.42) and2.69(2.13～3.27), respectively.6. The area under the curve (AUC) of SBP, DBP, TG, TC, HDL-C, LDL-C and FPG were:0.64(0.49～0.78),0.62(0.57～0.67),0.87(0.84～0.91),0.62(0.57～0.68),0.57(0.43～0.74),0.60(0.53～0.77).Conclusions1. The prevalence of hyperuricemia for males is higher than females in civil servants of Zhengzhou. Males aged30～and females aged60～are the high risk group for HUA.2.The major independent risk factors for hyperuricemia are hypertension, hypertriglyceridemia. hypercholesterolemia, high low-density lipoprotein hematic disease, low high-density lipoprotein hematic disease and hyperglycemia. The common risk factors for hyperuricemia have high exposed clustering status in the civil servants.3. The TG is more effective than other factors to the diagnosis of HUA.