Clinical Observation Of Renal Function Index In Patients With Primary Hypothyroidism

The primary thyroid hypofunction is caused due to the lesions of thethyroid gland itself. Pathology of hypothyroxinemia, is characterized by theaccumulation of mucopolysaccharides in the tissue and skin, manifested asmyxedema. More common in women, occurs in young and middle-aged,maleto female ratio is1:5to10, a major cause of autoimmune damage: The mostcommon cause is autoimmune thyroiditis, including Hashimoto’s thyroiditis,atrophic thyroiditis, Subacute lymphocytic thyroiditis and postpartum thyroid-ditis;thyroid destruction: including surgery, radioactive iodine treatment;3.excess iodine: Iodine excess can cause the potential thyroid disease ashypothyroidism, which can also induce and aggravate autoimmune thyroiditis;antithyroid drugs such as lithium salts, thiourea, etc.. With the incidence ofhypothyroidism, the level of China’s economic development and popularizationof iodized salt significantly reduced the general population prevalence of0.8to1.0%. Began in March2009, completed in August2010, encompassed10cities,including Beijing, Chengdu, Guangzhou, Guiyang, Jinan, Nanjing, Shanghai,Shenyang, Wuhan, Xi’an and other thyroid diseases, epidemiologicalinvestigation showed thyroid hypothyroidism suffering from serious illnessincreased significantly, reached6.5%. In recent years, repeated clinicalhypothyroidism can cause kidney damage. Two cases of change such as foreignden Hollander, and37cases of hypothyroidism in patients with renal damageand four cases of hypothyroidism studied by Mooraki due to acute renal failurein patients with clinical observation, domestic Dingqi Long thyroid functionhypothyroidism and impaired renal function. This primary thyroidhypofunction induced renal damage caused by academic attention since its pathogenesis is not clear, view of this comparative analysis of the past threeyears, our hospital information in23cases of primary thyroid patients withhypothyroidism, and23cases of the same sex, age constitute healthy controls,testing of the original acid free thyroid, free thyroxine, thyrotropin, creatinine,urea nitrogen, creatinine clearance, urine protein; observed in patients withprimary hypothyroidism simply levothyro-xine replacement of renal functionchanges before and after treatment for part of the refractory cases, given thecombination of small doses of hormones (prednisone0.5to1.0mg/(kg.d));observation group and control group, age composition and the comparisonbetween applications independent samples t-test, paired t-test of indicatorschange before and after treatment, urinary protein positive rate of application ofchi-square test to observe joint corticosteroid treatment to make the leveldiagram。Objective：Observed in patients with primary hypothyroidism kidneyfunction indicators, and indicators of renal function after treatment change。Methods：Nearly the past few years in out hospital, female patients withprimary hypothyroidism patients in the observation group and23cases ofhealthy patients (both hospital medical women, no kidney disease history) asthe control, detection of the original acid free thyroid, free thyroxinethyrotropin,creatinine, urea nitrogen, creatinine clearance, urine protein, observed changesin the patients with primary hypothyroidism simply levothyroxine replacementtherapy before and after renal function indicators, and related statisticalanalysis; for some refractory cases,given the combination of small doses ofhormones (prednisone0.5to1.0mg/(kg.d))。Results：Index hypothyroidism urea nitrogen, creatinine in the observationgroup is higher than that in the control group, creatinine clearance is lower thanthe control group; pure levothyroxine replacement therapy measured creatinine,urea nitrogen, urinary protein were lower than before in treatment group; high level of creatinine clearancegroup before treatment; the application of smalldoses of the hormone group can relieve some of the refractory patients。Conclusion：1. Patients with primary hypothyroidism may have varying degrees ofrenal dysfunction;2. Pure levothyroxine replacement therapy can reverse some of the kidneydamage, early diagnosis and timely treatment are necessary。3. Primary hypothyroidism associated with proteinuria in patients withineffective pure levothyroxine replacement therapy may combine with hormonetherapy。...