The Detection And Significance Of S100A13 In Serum With Psoriasis Vulgaris

Objective:To study whether S100 proteins A13 is associated with the incidence of psoriasis vulgaris, correlated its amount with disease severity. Methods:Serum obtained from psoriasis vulgaris patients and from healthy individuals was detected for S100A13 levels by enzyme-linked immunosorbent assay(ELISA). Results:Light psoriasis vulgaris patients showed serum levels of 66.172±22.076μg/L (mean±SEM, n=20), Heavy psoriasis vulgaris patients showed levels of 168.492±101.127μg/ L(n=20) and healthy controls presented with 40.075±10.338μg/L (P<0.01). Conclusions:The data demonstrate that hyperproliferation and abnormal differentiation of psoriatic skin is associated with a massive upregulation and secretion of S100A13, suggesting S100A13 is probably not only associated with the incidence of psoriasis vulgaris, but also positively correlated with disease severity of psoriasis vulgaris.