| Objective:To investigate the pharmco-chronological effect of irbesartan on BPand circadian rhythm in elderly non-dipper hypertensive patients.Method:One hundred and twenty elderly patients with non-dipper pattern ofnightBP were were divided into morning dose(n=60) and evening doseprogram(n=60) were treated with irbesartan (150 mg/d) for 8 weeks.Themorning dose program were treated with irbesartan at am 7:00-8:00 andthe evening dose program were treated with irbesartan at pm 7:00-8:00.Dynamic monitor patients 24-hour ambulatory blood pressure, twoprograms of 24 hours after treatment during the day and night averageblood pressure, blood pressure the statistical analysis on average.Results(1) the two program compared before and after the treatment of bloodpressure, difference was statistically significant (P < 0.05). Beforetreatment compared, blood pressure difference was statisticallysignificant (P > 0.05). After treatment, dSBP 24h SBP, dDBP 24h 24hDBP, PP, comparison, difference was statistically significant (P > 0.05),after treatment night systolic pressure, diastolic pressure difference wasstatistically significant comparative, (P < 0.01).(2) The morning dose program of patients 24 h SBP success rate for33.33% , dSBP success rate for 51.67% , evening dose program ofpatients 24 h SBP success rate for 36.67% , dSBP success rate for 46.67%( P > 0.05). The nSBP success rate for morning dose program was 35.00% , the nSBP success rate for evening dose program was 71.67 % ( P <0.01).(3) After the treatment of two program of blood pressure circadianrhythms change was significant difference (P < 0.01). ConclusionBoth morning and evening programs of irbesartan administ ration wereeffective indecreasing night BP(P<0.01). Compared with morningprogram , evening program might be more effective in decreasingthe highnight BP load and alteration f rom non-dipper to dipper pattern.
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