| BackgroundSince HIV was found in 1981, it spreads around the world rapidly. HIV transmission from homosexual behavior accounts for 12.2% among newly found positive cases in 2007 in China, which has turned to be the main HIV transmission route spreading AIDS from high risk population to general ones in our country. Current AIDS epidemic situation in China shows low prevalence in general and clusters of high prevalence in certain subgroups and subareas. While men who have sex with men (MSM) groups face severe threaten of HIV infection.Male circumcision can reduce risk of HIV acquisition among heterosexual men, but its effectiveness is uncertain among MSM and its acceptability among Chinese men is unknown given a lack of history and cultural norms endorsing neonatal and adult circumcision.Experience and lessons from global AIDS prevention indicate that the best method for infectious disease prevention is mass vaccination. Vaccination will also be an important method for human to conquer AIDS epidemic. New Anti HIV vaccine developed by NCAIDS demonstrates protective function in anti virus experiments among monkeys, and has approved by FDA in China. It has good result in phase Ia clinical trial. And phase Ib clinical trial is now undergoing. Large scale of high risk population will be enrolled to attend the clinical trial when it goes to phase II and III.Objectives:1. To investigate the epidemic situation of HIV/AIDS in Chaoyang District;2. To investigate the willingness to participate (WTP) in a clinical trial of circumcision to prevent HIV infection among MSM;3. To investigate the willingness to take Anti HIV vaccine among MSM.Methods and Contents:1. HIV/AIDS epidemic situation of Chaoyang District was investigated through analysizing data base of confirmed HIV positives in Chaoyang District from 1st Jan. 2000 to 31st Dec. 2007.2. Questionaire survey among 284 MSM was carried out in VCT clinic of a district Hospital from September to November in 2007. The contents of survey include Demographic characteristics of participants, sexual behavior in the past three months, behavior practise in the past three months, history of circumcision and perception on male circumcision.3. Questionaire survey was carried out in VCT clinic of a district Hospital fromMarch to June in 2007. The contents of survey include Demographic characteristics of participants, sexual behavior in the current 3 months, behavior practise in the current 3 months and the knowledge of benefits and risks of participation in vaccine clinical trials.Results:1. The number of confirmed HIV positive cases has an apparently increasing tendency. The number of male, flouting population, MSM and people aged from 20 to 30, has increased rapidly in recent years. And these cases account for a significant amount of all HIV positives in our District.2. Of 284 participants who have never been circumcised, 48 (16.9%) reported that they were absolutely willing to participate; 75 (26.4%) were probably willing to participate. Multivariate Logistic regression model analysis showed that three variables are independent predictors for willingness to participate in a circumcision trial. Those who did not have a Beijing resident card (adjusted odds ratio [AOR], 1.99; 95% confidence interval [CI], 1.17-3.38), did not find sexual partners through Internet (AOR, 2.13; 95% CI, 1.21-3.75), and were not concerned about the effectiveness of circumcision (AOR, 2.37; 95% CI, 1.34-4.19) were more likely to be willing to participate in a trial.3. Of 550 participants, 197 (35.8%) reported that they were absolutely willing to participate; 193(35.1%) in a clinical trial of Anti HIV vaccine. Multivariate logistic regression model analysis showed that family support (AOR, 17.83; 95% CI, 7.61～41.77), the possible protect from the vaccine (AOR,2.89, 95%CI: 1.65～5.07)and the peer pressure of participating Anti HIV vaccine clinical trial (AOR,0.46, 95%CI: 0.31～0.70) were the main factors which affect the willingness of participating in the trial.Conclusions:1. The number of confirmed HIV positive cases has an apparently increasing tendaacy. And MSM have been the main group of HIV infection.2. There is a high proportion of MSM in our country who are willing to receive circumcision to prevent HIV. Thus enrollment in targeted population for this clinical trial is practical.3. Intensifying publisizing and increasing the awareness of Anti HIV vaccine will facilitate the enrollment of volunteers of clinical trials. |
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