Clinical Pathological Study Of Retinoblastoma And The Significance Of Egfr, Ki67

[Objective] :To study the relationship between the clinical and pathological data of retinoblastoma(RB) patients . To investigate the significance of expression of EGFR and Ki67 in retinoblastoma. [Methods] :1. In this retrospective study, the clinical and pathologic data of 46 retinoblastoma patients admitted in 4 hospitals in Jinan over the years 1990 to 2004 were reviewed. Statistical analyses on sex, age at symptoms, laterality, duration of symptoms .clinical findings, staging of RB, histological typing and the condition of optic nerve invasion.2. To detect the expression of EGFR and Ki67 in retinoblastoma(RB) , the immunohistochemistry method was used. All data were analyzed statistically with SPSS. [Results] :1. In this series of the 46 RB cases , there were 25 male patients with 25 eyes sickened and 21 female patients with 21 eyes sickened, male : female =1.2 : 1; there were 20(43.5%) left eyes, 26(56. 5%)right eyes. All were odd eyes and given the extirpate surgery. Ages at symptoms were from 24 days to 11 years old, average 3. 52±1. 60 years with most patients (65. 2%) younger than 3 years old; duration of symptoms from 3 days to 1 years, average 53.5±52.89 days; leucocoria was the most common symptom of patients (31 cases 67%)while others clinical symptoms were lost of eyesight(5 cases 11%).2. Clinical results: There were 26 cases(56.5%) belong to intraocular developing stage; 12 cases (34.8%) belong to ocular hypertonia stage; 8 cases (17.4%) belong to extraocular developing...