The Correlation Of Presentation Of Ki67, P53and EGFR In Gastric Cancer

Background and ObjectivesGastric cancer is one of the most frequent malignant diseases in the world, and it remains extremely common among men in certain regions, such as tropical South American, some parts of the Caribbean, Eastern Europe, Japan and China. China is one of the countries in which the incidence rate of gastric cancer is higher, approximately42%of the new cases of gastric cancer per year worldwide come from china. The incidence rate and fatality rate of gastric cancer in our country are higher than the average level in the world. The incident of gastric cancer was in the second place among the major malignant tumors of our country, and the fatality rate ranked the third. Gastric cancer has become one of the serious threaten to public health in our country, and exerted severe negative effect on people’s life. With the progress of treatments, the survival time of patients with gastric cancer has been extended significantly, but the fatality rate of gastric cancer still maintains a high level, so the study of the pathogenesis of gastric cancer is of especially significant. Although, the pathogenic factors of gastric cancer are well known, the mechanism of gastric cancer development has not been illustrated completely. P53gene is one of the tumor suppressor genes and related to the occurrence and progression of malignant tumors. EGFR is a kind of membrane receptor which was over expressed in various kinds of malignant tumors. Object and methodA total of61gastric cancer tissue samples from operation are collected, including51men and10women, arrange from21to85. All patients did not receive chemotherapy and radiotherapy. The expressions of EGFR, Ki67antigen and p53were detected by immunohistochemistry.ResultsThe positive expression rate of EGFR, Ki67and p53in canoer tissue were42.6%,55.7%and88.5%, the positive expression rate of EGFR, Ki67and p53in adjacent normal tissue, respectively. The expression of EGFR, Ki67antigen and p53were not statistically correlated with gender, age and tumor size (P>0.05).EGFR expression was significantly correlated with infiltrative depth, lymphatic invasion and distant metastasis (P<0.05). P53expression was significantly correlated with tumor location, differentiation degree, infiltrative depth and distant metastasis (P<0.05). Ki67antigen expression was significantly correlated with differentiation degree, lymphatic invasion and distant metastasis (P<0.05). EGFR expression was positively correlated with Ki67(r=0.241, P=0.036). P53expression was positively correlated with Ki67antigen (r=0.306> P=0.017). NO significant correlation was found among EGFR and P53(r=0.019, P=0.893)ConclusionsThe anomalous expressions of EGFR, P53and Ki67existed in the tissue of gastric cancer, indicating that there was a close association between the abnormal expression and the occurrence and progression of gastric cancer; there were complex relationship among EGFR, P53and Ki67, the co-detection of these proteins might have important value for diagnosis and the estimate of prognosis of the disease.