| Objective.To observe the clinical effect of on bronchial asthma and to explore it's possible mechanism at a molecular level.Methods:60 patients of bronchial asthma were randomly divided into treatment group and control group, the treatment group treated by Tinglong Tang,and the control group treated by conventional medical treatment. the changes on symptomatic signs of asthma,pulmonary function,serum IgE,serum IL-4,and IFN-γwere observed before and after treatment.Results:There is significant difference in clinical effect between the two groups (p<0.05).There is significant difference in symptomatic signs between the two groups (p<0.05).The pulmonary function is improved apparently in the treatment group compared with control group (p<0.05). No significant difference is found between the two groups in IL-4 and the discrease level of the serum IgE,the increase level of IFN-γis up-regulated apparently in treatment group compared with the control group (p<0.05).Conclusion:1. Tinglong Tang is superior to conventional medical treatment in clinical effect in treating mild acute attack of bronchial asthma.2. Tinglong Tang can improve pulmonary function and down-regulate the serum IgE level,and has the function of relieving asthma and inhibiting immunization.3.Tinglong Tang can improve the level of serum IFN-γ,down-regulate the level of serum IL-4,regulate Th1/Th2,and relieve the chronic inflammation,thus relieve hyperactivity of the airway. 4.The possible mechanism of Tinglong Tang in treating bronchial asthma is explored in this research. It provides theoretical base for treating bronchical asthma. |
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