Systematic Evaluation On The Effectiveness And Safety Of Treating Asthma In Children With Shegan Mahuang Tang Modified

PurposeThis paper is intended to make a systematic evaluation upon the effectiveness and safety of treating asthma in children with the syndrome-based medical method, which has been known worldwide for providing quality evidence for clinic research. Besides,30cases are collected for parallel comparison in clinic.Methods1,Systematic evaluation part:according to the systematic evaluation method by the international Cochrane collaboration website, random/semi-random controlled trials or clinic controlled trials about treating asthma in children with Shegan Mahuang Tang Modified are retrieved from such databases as:CNKI serial database(1979.1-2012.2), CQVIP database for Chinese sci.&tech. journal(1989.1-2012.2), Wanfang digitalized journal full-text database, Wanfang China’s academic meeting dissertation full-text database(1997.1-2012.2), Cochrane Library and Pubmed. Experimental investigations meeting the acceptance standards are selected from all literatures to undergo a quality assessment and data extraction. The evaluation process is worked out in a strict way with the overall effectiveness and untoward effect of treating asthma in children with Shegan Mahuang Tang Modified as the index.2,Clinic observation part:the60cases of children(aged between3and18) diagnosed with asthma are divided into two groups, the treatment one and control one,30cases each. The treatment group is to orally take Shegan Mahuang Tang Modified, while the control one to undergo normal Western treatment for equally7days. Primary clinic symptoms and physical sign ratings of children from both groups before and after treatment at the0,4and7day are observed and recorded. Eventually the data are collected and arranged for statistics handling and analysis. Results1,Systematic evaluation part:8literature studies, totaling846infant patients, are involved according to the quality assessment standard of systematic evaluation. Bias risk of all literatures involved is undetermined. Meta analysis results show the over effect ORcombined=4.29, with its95%confidence interval ranging from1.70to10.79, and its Z value and P value of test for overall effect respectively3.09and0.002. The difference is meaningful in statistics, proving the control group treated by Shegan Mahuang Tang Modified is better in effect.2,Clinic observation part:1) in terms of comprehensive curative effect, the display control rate and overall effectiveness rate of the treatment group are respectively80%and96.7%; while those of the control group respectively77.0%and100%, with χ2=0.75, P=0.99and P>0.05. The difference is meaningless in statistics, indicating an equal effectiveness between the two groups.2) primary symptoms and physical signs of asthma:through paired t-test statistics analysis, primary symptoms and physical signs of children from both groups are improved apparently before and after the treatment, with P=0.00(P<0.05), indicating effectiveness of both treatment methods. The comparison of primary symptoms and physical signs between the treatment group and control one is meaningless in statistics(P>0.05), indicating the two groups are equivalent in mitigating the gasp, wheeze in the lung, cough, expectoration and anhelation.3) comparison of secondary symptoms at acute phase of cold asthma:the treatment group shows apparent difference in relieving secondary symptoms such as sweating, pale compression, fever with aversion to cold, anorexia, warmth lack in limbs, and tongue and pulse signs(P<0.05).4) treatment group’s total difference of secondary symptoms before and after the treatment is meaningful in statistics(P=0.00<0.05).Conclusion1,Systematic evaluation part:it cannot be neglected that treating asthma in children with Shegan Mahuang Tang Modified is effective clinically. Howev er, as existing researches are all made by experiment in small samples, a metho d to be improved, more precise clinic experiments featuring large sample, multi-center, random and comparison shall be taken to render quality evidence for the clinic effectiveness of treating asthma in children with Shegan Mahuang Tang Modified.2,Clinic observation part:relatively favorable effectiveness can be seen in both treatment of slight and intermediate asthma(cold-pattern) in children at the acute stage. While both methods can mitigate or remove the symptoms and physical signs of the infant patients at acute stage such as gasp, anhelation, wheeze in the lung, cough and expectoration, the treatment group acts better than the control one in improving such secondary symptoms as sweating, pale expression, fever with aversion to cold, anorexia, warmth lack in limbs and tongue and pulse signs. As showing no apparent untoward effect and favorable compliance, the method used in treatment group is widely welcomed among patients and a reward to be promoted in clinic use.