| Purpose:Palmoplantar pustulosis is one of clinical refractory skin disease.Its skin lesions against palm and plantar part of the patient, affecting the patient’s daily labour and walking.It is a Lingering illness, features recurrent frequently, causing serious distress to the patient’s body and mind and reducing the life quality of the patients. In this study,we observe the efficacy of Shi Lan Cao Decoction for the treatment of palmoplantar pustulosis, compare and analysis of the differences of the curative effect between traditional Chinese medicine therapy and western medicine treatment, making an objective evaluation, in order to explore a new treatment option and provid reference for the treatment and prevention of palmoplantar pustulosis.Material and method:The whole 72 palmoplantar pustulosis patients selected from March 2014 to March 2015 visiting in the dermatology clinic of the Affiliated Hospital of Liaoning University of traditional Chinese medicine.Using randomization method, we classified the patients as traditional Chinese medicine group(treatment group) and Western medicine group(control group).Each group had 36 cases.The treatment group was treated with traditional Chinese medicine decoction(Shi Lan Cao Decoction)100 ml, 2 times a day orally;the control group received Bai Shao Zong Gan Jiao Nang 0.6g,2 times a day orally; both two groups were treated with topica assisted treatment. We put 6 weeks as a course. both two groups were received two courses of treatment. After each course of treatment continuously,we observe the patients’ symptoms.All the patients were followed up for 6months to collect their recurrence.Results:1.At the end of the first course of treatment, the differences of two groups of patients’ score were no statistical significance(t=-0.035,P=0.972>0.05), the total efficiency of the treatment group was 34.29%, while the control group was 41.67%. The results showed that after 6 weeks of treatment, Shi Lan Cao Decoction and Bai Shao Zong Gan Jiao Nang has almost the seam effect.2. At the end of the second course of treatment, the two groups of patients’ score showing asignificant difference(t=-3.855,P=0.000<0.05),the total efficiency of the treatment group was 91.18%, while the control group was 64.51%. The results showed that after 12 weeks of treatment, Shi Lan Cao Decoction has better curative effect than Bai Shao Zong Gan Jiao Nang.3.At the end of treatment, two groups of patients with pruritus symptoms were relieved(P <0.05), the antipruritic effect total efficiencyof the treatment group was 70.59%, while the control group was 45.16%, which is indicated that the antipruritic effect of traditional Chinese medicine decoction was significantly better than Bai Shao Zong Gan Jiao Nang.4. In the two follow-up, compaired with the end of treatment,the patients’ scores have varied degrees of increase.For the overall analysis, the treatment group is still lower than the control group.In the second follow-up,the treatment group’s recurrence rate was 32.14%, while the control group was 78.95%, which indicated that the treatment group has better curative effect than the control group.Conclusion:1.Shi Lan Cao decoction can effectively improve the symptoms of patients with palmoplantar pustulosis.2. For the treatment of palmoplantar pustulosis,Shi Lan Cao Decoction is superior to that with Bai Shao Zong Gan Jiao Nang treatment.And the long-term recurrence rate is lower than the control group, it is worth to clinical application. |
