Study On The Bloodlipid Metabolism, Urinary Trace Elements And The Metabonomics In Uygur MODY Diabetic Pidigrees

Objective:To investigate the level of blood lipid, urinary trace element, and the product of metabolism in urine for Uygur MODY diabetic pedigrees from Kashikar city of Xinjiang Uygur Autonomous Region. To discuss the characteristics of change of blood glucose and lipid metabolism, the correlation between urinary trace element content, blood glucose and lipid, and the product of metabolism in urine. In order to find out the clinical features of Uygur, go on health education, as well as the prevention and control of diabetes, it can provide theoretical basis.Methods:Two Uygur MODY diabetic pedigrees from Kashikar city of Xinjiang Uygur Autonomous Region were involved in this research with their informed consents. The members'general information were collected, the blood glucose level, blood lipid level, urinary trace elements contents ( include zinc, copper, ferrum, maganese, calcium, manganese, selenium, argentum, plumbum and cadmium ) and product of metabolism in urine were analysed. All of the pedigrees members were divided into 2 groups according to the new diagnostic criteria of diabetes by the World Health Organization ( WHO ) in 2006:â‘ the euglycemia group: A total of 46 cases, male 22 cases, female 24 cases;â‘¡the diabetes group: A total of 9 cases, 5 males and 4 females. Results:â‘ The age of the members in euglycemia group was younger than the diabetes group, P<0.05; the level of systolic blood pressure and diastolic blood pressure of the members in euglycemia group was lower than the diabetes group, P<0.05; the statistical differences in the low density lipoprotein cholesterol ( LDLC ) levels between euglycemia and diabetes groups were obviously, P<0.05.â‘¡The fasting blood glucose and postprandial blood glucose are positively correlated with the age; The levels of CHOL, LDLC and APOB are positively correlated with the weight and abdomen circumference; The levels of postprandial blood glucose, CHOL, LDLC and APOB are positively correlated with the systolic blood pressure and diastolic blood pressure; The level of CHOL is positively correlated with the fasting blood glucose, postprandial blood glucose and levels of other blood lipid, P<0.05.â‘¢The urinary content of ferrum in diabetes group was lower than the euglycemia group, P<0.05; The urinary content of Mn in diabetes group was higher than the euglycemia group, P<0.05. Correlation analysis showed that: there were positive correlations between the urinary content of magnesium and calcium; the magnesium and zinc level, the copper and zinc level, the ferrum and zinc level, the ferrum and copper level, the plumbum and copper level, the manganese and cadmium level, P<0.05; while there is no correlation was found between blood glucose level and urinary trace element content in this two Uygur MODY pedigrees, P>0.05.â‘£The differences in the product of metabolism in urine of the MODY diabetic pedigrees members were obviously, the content of Glutamic Acid and Acetylglutamic Acid rised, and Citric Acid , Trimethylamine Oxide , Trimethylamine Ammoniated reduced. Conclusion:â‘ Abnormal lipid metabolism is presented in NGT relatives of MODY diabetic pedigrees;â‘¡Correlation between trace elements contents in urine is obviously.Trace elements are missing from urine in the MODY diabetic pedigrees members.â‘¢The etiopathogenesis of diabetes is correlated with abnormal krebs citric acid cycle and glucolysis tightly;â‘£The MODY diabetic pedigrees members were the high risk group of diabetes, it is very important to balance the trace element and the fat content from daily diet. This result indicate that the daily diet education needs to be strengthen in order to prevent and to treat the diabetes.