| 0bjective:Retrospective analysis the changes and characteristic of drug therapy to the patients with chronic heart failure(CHF)of the Second Affiliated Hospital, Chongqing Medical University in 1990,2000 and 2010. Investigate the gap between current conditions and domestic and foreign guide. Hereby to provide evidence for more safe,efficient and economical medication,reduce the course of Chronic Heart Failure and improve the quality of life of the Chronic Heart Failure patients.Methods: To take the patients with chronic heart failure of the Second Affiliated Hospital of Chongqing Medical University in 1990, 2000 and 2010, all the patients with heart failure questionnaire had been registered one by one according to the requirement of The CHF Inventory of China.Results : In recent 20 years,Medication of Heart Failure during hospitalization were still mainly based on diuretics, nitrates, and digitalis-based in The Second Affiliated Hospital of Chongqing University of Medical Sciences. The application rates of the drugs was respectively 85.25%,51.64%,57.21% in 1990,2000 and 2010. The high application rates of diuretic was respectively:93.75%,85.95 %,83.12 % , it has no significant difference in 1990,2000,and 2010. But the application rate of digitalis dropped from 70.00%, 66.56% in 1990 and 2000 to 41.13% in 2010. To comparison in 1990,2000 and 2010,it has significant difference(χ~2=40.46 ;P﹤0.01). The decreasing application rates of nitrates in 1990, 2000, 2010 was respectively 67.50%,64.88%,29.00%.To comparison in 1990,2000 and 2010,it has significant difference(χ~2=76.45, P﹤0.01 ).In 1990,2000 and 2010 year, the application rates ofβ-blocker was respectively 0% , 42.47% , 43.72%.The application rates of angiotensin—converting enzyme inhibitors/angiotensin receptor blocker(ACEI/ARB) was respectively 7.50% , 77.26%,78.35% .The application rates ofβ-blocker and angiotensin—converting enzyme inhibitors/angiotensin receptor blocker(ACEI/ARB) are Upward trend and become chief drug for Chronic Heart Failure. But the daily dose is lowness.The Mean daily dose of Metoprolol tartrate is only 13.17% of dosage recommended by The Chinese Guide[1], which is commonly uesd inβ-blocker. The Mean daily dose of Perindopril, which is commonly uesd in ACE-inhibitors, lower than those of dosage recommended by The Chinese Guide[1] and corresponded to 48.25% of the recommended dose .In 1990,2000 and 2010,the application rates of spironolactone was showed an up trend and was respectively 43.75% 57.86%,74.46%. To comparison in 1990,2000 and 2010,it has significant difference(χ~2=27.97,P﹤0.01 ). spironolactone was mainly used in NYHA-functional classesⅢ,ⅣCHF patients. The application rates of spironolactone used in NYHA-functional classesⅡCHF patients were increasing year after year and was respectively 3.75%,26.92%,65.00% in 1990,2000 and 2010.To comparison in 1990,2000 and 2010,it has significant difference(χ~2= 24,65,P﹤0.01). Currently, calcium channel antagonists is not recommended as a guide to the main drug therapy of heart failure. There was a low application rate of Calcium channel blockers of 25.41% in whole sample, and it mainly(88.78%) used in Chronic Heart Failure patients that caused by high blood pressure.Conclusion:The treatment of heart failure were mainly based on medication of traditional medicine(sdiuretics, nitrates, and digitalis-based), but has been a change of fundamental conceptual. The application rates ofβ-blocker and angiotensin—converting enzyme inhibitors/angiotensin receptor blocker(ACEI/ARB) has increased markedly from 2000.But the use rate still has instinct gaps compared with the recommended dosage of Treatment Guidelines[1] for Chronic Heart Failure of China.
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