| Objective:To observe the constituent ratio and the dynamic constituent ratio of bone tumor and tumor～like lesions in different era. To summarize the distribution characteristics of bone tumor and tumor～like lesions in different positions of the body and different age.Methods:All pathology data of bone tumor and tumor～like lesions in pathology department of the Third hospital of Hebei medical university(1963～2007)were assembled, and the case history were analyzed. Then these data was inputed to computer and statistical analyzed by SPSS13.0.Results: 6322 cases of bone tumor and tumor～like lesions were collected. There were 2026(32%) malignant and 3300(52%) benign lesions, 996(16%) tumor～like lesions. The male and female cases were 3672(58%) and 2650(42%) respectively in all cases, the ratio of male to female was about 1.39:1. The bone tumor and tumor～like lesions could appear in all ages, and occurred most frequently in the 11～20 years old(32.7%) and 21～30years old(18.2%). The male cases were 1868(57%) and the female cases were 1432(43%) in the benign lesions. The male cases were 1203(59%) and the female cases were 823(41%) in the malignant lesions. The male cases were 601(60%) and the female were 395(40%) in the tumor～like lesions. The most common bone tumor and tumor～like lesions was osteochondrma 1447(22.9%), the following were osteosarcoma 692(10.9%), metastatic tumors 594(9.4%), giant cell tumors 554(8.8%), chondroma 427(6.8%), fibrous dysplasia 411(6.5%), simple bone cyst 297(4.7%), chondrosarcoma 190(3%), chondroblastoma 128(2%), osteoma 111(1.8%), langerhans cell histiocytosis 101(1.6%), and malignant fibrous histiocytoma 101(1.6%) in order of frequency. The solitary cases in femur were 1709(the common neoplasm in descending order were osteosarcoma, osteochondroma and giant cell tumors), tibia were 1367(in descending order were osteochondroma, osteosarcoma and giant cell tumors), fibula were 190(in descending order were osteochondroma, osteosarcoma and giant cell tumors), humerus were 483(in descending order were osteochondroma, simple bone cysts and osteosarcoma), radius were 98(in descending order were giant cell tumors and osteochondroma), ulna were 60(in descending order were osteochondroma and giant cell tumors), skull were 41(the most common neoplasm was osteoma), jaw were 114(the most common neoplasm was adamantinoma), the vertebral column but vertebrae sacrales were 256(the most common neoplasm was metastatic tumor), vertebrae sacrales were 141(the most common neoplasm was notochordoma), ilium were 264(the most common neoplasm was metastatic tumor), pubis were 77(the most common neoplasm was metastatic tumor), ischium were 42(the most common neoplasm was metastatic tumor), scapula were 136(the most common neoplasm was osteochondroma), the clavicle were 46(the most common neoplasm was metastatic tumor), sternum were 20(the most common neoplasm was metastatic tumor), ribs were 88(the most common neoplasm was fibrous dysplasia ), patella were 21(the most common neoplasm was Chondroblastoma), metacarpus were 90(the most common neoplasm was chondroma), phalanges of fingers were 268(the most common neoplasm was chondroma), the tarsale were 63(the most common neoplasm was Chondroblastoma), metatarsals were 24(the most common neoplasm was osteochondroma), phalanges of toes were 62(the most common neoplasm was subungual exostosis). The all cases examined through histopathological method in every era(and average cases examined every year) in order of frequency were 532(76), 1624(162.4), 3195(319.5), 5242(524.2) and 6850(856.3) respectively from 1963 to 2007. The all osteosarcoma cases diagnosised in every era from 1963 to 2007(the constituent ratio and average cases every year) were 22(4.1%, 3.1), 105(6.5%, 10.5), 165(5.2%, 16.5), 183(3.5%, 18.3) and 217(3.2%, 27.1) respectively. The all metastatic tumor were 13(2.4%, 1.9), 56(3.4%, 5.6), 96(3%, 9.6), 161(3.1%,16.1), 268(3.9%, 33.5) respectively. The all chondrosarcoma were 11(2.1%, 1.6), 23(1.4%, 2.3), 36(1.1%, 3.6), 67(1.3%, 6.7), 53(0.8%, 6.6) respectively. The all giant cell tumor of bone were 37(7%, 5.3), 91(5.6%, 9.1), 113(3.5%, 11.3), 155(3%, 15.5), 159(2.3%, 19.9) respectively. The all chondroma of bone were 22(4.1%, 3.1), 39(2.4%, 3.9), 84(2.6%, 8.4), 124(2.4%, 12.4), 158(2.3%, 19.8) respectively. The all fibrous dysplasia of bone were 2(0.4%, 0.3), 38(2.3%, 3.8), 65(2%, 6.5), 119(2.2%, 11.9), 187(2.7%, 23.7) respectively. The all osteochondroma were 35(6.6%, 5), 107(6.6%, 10.7), 196(6.1%, 19.6), 415(7.9%, 41.5), 499(7.3%, 62.4) respectively. The all myeloma were 1(0.2%, 0.125), 2(0.1%, 0.2), 18(0.6%, 1.8), 14(0.3%, 1.4), 60(0.9%, 7.5) respectively.Conclusion: The sex ratio of male to female in all bone diseases was 1.39:1. The most common malignant tumors were osteosarcoma, metastatic tumors, and chondrosarcoma in order of frequency. The most common benign tumors were osteochondroma, giant cell tumors and chondroma in order of frequency. The most common tumor～like lesions were fibrous dysplasia, simple bone cyst, and langerhans cell histiocytosis in order of frequency. The patients of bone tumor and tumor～like lisorders were mostly between the ages of 10-30. The most common sites of osteoma appeared in the craniofacial bone, osteoblastoma and hemangioma in spine, chondroma in metacarpus and phalanges of fingers, malignant lymphoma in femur and pelvis, chordoma in vertebrae sacrales, metastatic tumor in spine and femur, most of the rest of tumor in long bone. The most common neoplasm in distal radius was giant cell tumors, in proximate femur was fibrous dysplasia, in the ends of long bones was osteochondroma. The most common neoplasm in shaft of humerus and shaft of femur were metastatic tumor, in shaft of tibia was fibrous dysplasia, in skull was osteoma, in jaw was adamantinoma,in vertebrae but vertebrae sacrales was metastatic tumor. The most common neoplasm in ilium, pubis, ischium, clavical and sternum were metastatic tumor. The common neoplasm in scapula was osteochondroma, in ribs was fibrous dysplasia, in patella and tarsal bones were chondroblastoma, in metacarpus and phalanges of fingers were chondroma, in phalanx of toe and metatarsals were osteochondroma. All tumor of bone increased in different degree with era change. The constituent ratio of metastatic tumor increased in last decade, the constituent ratio of myeloma slowly increased year by year, the constituent ratio of osteochondroma increased in 90 era, the constituent ratio of osteosarcomatous descended from 70 era, the constituent ratio of chondrosarcomatous and giant cell tumors slowly descended year by year, the constituent ratio of chondroma and fibrous dysplasia did not change.
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