Analysis Of Constituent Ratio And Clinical Parameter Of Breast Cancer Between Changchun And Shanghai

Breast cancer is the most frequent malignant tumor for women .Rencently, the incidence continues to rise , breast cancer has becomean extremely important social economic issue in developing anddeveloped countries . Because some cases after operation may hadsome small clinical matastatic carcinoma , half of them will relapse ormatastasis . We may use some prognostic factors to discriminate thecases who tend to relapse , then give them completely adjuvanttherapies . We aimed to expore age , histopathology , the distrubitionof estrogen receptor (ER) , progesterone receptor (PR) and hunmanepidermal growth factor receptor-2 (HER-2) in breast cancer patientsand compared with clinical parameter .Objectiveto explore age , histopathology , axillary lymph node, ER , PR andHER-2'values in prognosis .Method898 patients were recruited , the estradiol receptor (ER) andprogesterone receptor (PR) were detected on 786 sections from casesof breast cancer tissues by enzyme linked immunosorbenthistochemical assay , the expression of proto-oncogene HER-2 wasdetermined simultaneously by immunohistochemical method .ResultBreast cancer in our country is younger and younger , and the mainhistopathological types is invasive ductal carcinoma . The incidence ofaxillary lymph node metastasis and the incidence of relapse of breastcancer in changchun is higher than shanghai .The incidence of relapseor metastasis of breasrt cancer in premenopausal patients was higherthan premenopausal ones (P ﹤0.05) .The ER(+) expression inpostmenopausal patients were higher than that of premenopausal ones(P﹤0.05) , while there was no significant difference between themense situation and the expression of PR and HER-2 ( P﹥0.05) . Thecorrelation coefficient between ER and PR was positive (P﹤0.05) ,while the correlation coefficient between HER-2 and ER ,PR wasnegative (P﹤0.05) . The expression of ER (+) PR (+) in patientswithout axillary lymph node metastasis were significantly higher thanthose in positive axillary lymph node ones (P﹤0.05) , contrarily , theexpression of HER-2 (+) in patients without axillary lymph nodemetastasis were significantly lower than those in positive axillarylymph node ones (P﹤0.05) . ER and PR negatively correlated withclinical TNM stages , but HER-2 positively correlated with them (P﹤0.05) . After 2 years follow-up , we found that regardless of theaxillary lymph node was positive or negative , ER have no significantvalues for prognosis , in the axillary lymph node positive group , therecurrence rates of PR (+) and PR(﹣) were 42.96% and 52.69%respectively (P﹤0.05) ; The recurrence rates of in HER-2 (+) andHER-2(﹣) were 59.95% and 35.70% respectively (P﹤0.05) . In theaxillary lymph node negative group , PR and HER-2 both have novalues in prognosis .In this study , we can see that in patients withhormone-receptor-positive disease, the odds of recurrence and deathwere reduced by 13.26% after 2 years of adjuvant endocrine therapy .