| Delayed menorrhea is a common gynecologic disease, belongs to category of menstruation disorder, and is part of category of uterine bleeding. In recent, diversification of therapy for delayed menorrhea with syndrome of phlegm-damp existed, such as western medicine,surgeon,acupuncture and moxibustion,decoction and herbs,massage and therapy of ear-pressure by bean, etc. Recent decade literature had reported that traditional Chinese medicine especially acupuncture and moxibustion,Chinese herbs could therapy this disease effectively and without adverse effect. Western medicine could take effect at the exact target but has adverse effect; and surgeon has huge reaction after operation. Thus, there has large advantage of acupuncture and Chinese herbs for the disease and its complications.In this research, we used modern scientific methodology, clinical epidemiology technique, combined modern scientific methods with traditional Chinese medicine to observe acupuncture plus Chinese herbs for delayed menorrhea with syndrome of phlegm-damp, establish clinical efficacy evaluation system of multiple index, and look for a standardized, effective and no adverse effect approach for treating with delayed menorrhea with syndrome of phlegm-damp(Tanshi type).ObjectiveTo evaluate objectively the clinical therapeutic effect and safety of acupuncture pus Chinese herbs for delayed menorrhea with syndrome of phlegm-damp, a randomized control trial was undertaken.MethodsSelect in the 2010 March to December 2010 in Taiwan during the ChenShuMei Chinese medicine clinics, accord with cases of 60 patients menstruation screening standards later patients. Using randomized controlled trials in research methods, patients were randomly divided into needle medicine combining 30 cases, Chinese traditional medicine group of 30 patients. Acupuncture location:close yuan, air sea, days in wan, foot barnado, sp6, Yin ling springs, FengLong, traditional Chinese medicine using five square. Add and subtract) scattered Even served for a period of treatment, around in a course of treatment is the line (stop taking 5). Menstrual cycle, observed before and after treatment by the quantity, the color, the qualitative change, menstrual later major clinical symptoms and signs, fundamental temperature changes, serum sex hormones (FSH and LH, E2, PRL, T), follicular size and safety testing and other projects. The outcome standard USES Chinese herbal drugs clinical research guiding principle in the late period of efficacy criteria to judge.Use Data3.1 Epi database software is built with SPSS17.0 statistical software, statistical analysis. Two groups of total curative effect, after treatment, clinical efficacy so clinical symptoms and signs statistical analysis, comparison, finally an objective evaluation of clinical efficacy and safety. Classified material with 2 inspection, level material with two sample Wilcoxon rank and inspection comparison (adjusted), two sample mean differences with t-test or compare Wilcoxon rank and inspection, own before-and-after with matching t test or Wilcoxon matching rank and inspection. Statistical graph were drawn by GraphPad. Prism 4.03 software.ResultsFour treatment after treatment, two groups of traditional Chinese medical syndrome total curative effect, regulate the menstrual function curative effect, disease comprehensive effect comparison, are statistically significant differences, needle medicine combining the total curative effect of traditional Chinese medical syndrome and greater 76.66%, with the total effective rate of 93.37%, traditional Chinese medicine group (which is 43.33%, 73.33%) high. Needle medicine combining group greater rate for menstrual function curative effect, the total effective rate 93.33% 83.33% respectively, which is 46.66%, traditional Chinese medicine group (73.33%) high. Needle medicine combining comprehensive effect of disease and greater 70.0%, with the total effective rate of traditional Chinese medicine group, which is 90.0% (33.3% 70.0%), high. Clew needle medicine combining group of TCM syndrome, in improving the menstrual function and comprehensive curative effect, treatment phlegmy wet type than the total curative effect later disease menstruation curative effect of traditional Chinese medicine.Menstrual improvement:two groups after treating menstrual quantity improve degree was statistically significant comparative, differences (P< 0.05). Monthly menstrual cycle, the improvement of comparison, difference was statistically significant:Menstrual cycle, menstrual period, by volume comparison, complex often rate difference was statistically significant. By statistics knowable, needle medicine combining group menstrual quantity improve degree is good curative effect of traditional Chinese medicine. Needle medicine combining to other indicators (of menstrual cycle, menstrual improve degree and the menstrual cycle, menstrual period, by volume after often rate) all have certain degree of improvement, and more Chinese medicine group after often rate is high, but the two groups of comparisons was statistically significant.Main accompany symptoms:two groups after treating the line down capacity is much, diarrhea, eat less disappear rate quite, abdominal distension difference was statistically significant (P< 0.05). Scanty periods is lubricious weak, palpitation and shortness of breath, dizziness, face foot dropsy, lip lubricious weak, chest tightness, defecate rare pond often compared, such as difference were disappearing rate was not statistically significant. Tip:both groups can improve the clinical symptoms, mainly menstrual late in the improvement of needle medicine combining the line down capacity is much, diarrhea, eat less abdominal distension symptoms curative effect is distinct.Serum sex hormone levels, fundamental temperature and maximum follicular diameter:both groups can effectively reduce serum sex hormones FSH menstrual later patients (follicle-stimulating mature grain), LH (luteinizing), PRL (prolactin), T (testosterone), increase serum E2 (estradiol), but the two groups of comparisons was statistically significant. Fundamental temperature: needle medicine combining temperature after often rate of temperature, Chinese traditional medicine group or 48.3% complex often rate 42.3%, both groups have improved, comparative difference was statistically significant. Maximum follicular diameter:two groups in menstrual cycle 12+1 day, the first 15 +1 day of follicular compare, all have statistically significant (P<0.05). Tip:needle medicine combining group, TCM group all can promote the patient of follicular, shorten follicular development. Curative effect of medicine combining with needles are better.Two groups, not appear during treatment of abnormal reaction acupuncture, drug allergy reaction and other adverse events. This means that two treatment safe and reliable.Conclusion1. Acupuncture treatment of traditional Chinese medicine with to improving phlegmy wet type of menstrual period and the related later patients with clinical symptoms are better effect. Better than pure herbal treatment.2. chinese medicines with acupuncture can promote follicular, shorten the fundamental temperature low temperature phase time and shorten the high and low temperature cell-extracellar period time.3. With acupuncture treatment and pure Chinese herbal treatment they improve phlegmy wet type menstruation reproductive endocrine hormone later patients FSH and LH, PRL, T, E2 level, both comparison, no significant differences.
|
PDF Full Text Request