| ObjectiveThis topic observation zhenwu tonga flavour to Yang generic heart failure water myocardial reconstruction, and related factor of the role of the clinical curative effect and the influence on the quality of life. Through the clinical research methods, prospective follow the principle of disease, Morrison for its medical clinical curative effect evaluation, proof zhenwu tonga flavour have anti-myocardial reconstruction effect, can improve the quality of life of the patients, the formulas for the modern medical basis for providing treatment for heart failure.Methods1.will meet the inclusion criteria of 60 patients using simple random packet method will attend experiments at random into two groups in treatment group control group,30 cases, each group.Two groups of patients were performed heart failure mission, such as limits on knowledge salt intake, salt daily 2-5g; Reduced physical activity and mental stress. Incentives treatment:the prevention and control of infection; Correct arrhythmia; Correct electrolyte disorders and acid-base disorders. Both groups using present "new standard therapy or conventional treatment", "ACEI andβreceptor blocker, diuretics, use or not land for high-octane therapeutic principles. "The control group (western medicine treatment group):and ShiWeiYa reached "shi (tianjin) pharmaceutical Co., LTD. Production, enterprise H20034053". being sponsored by:4mg, daily 1 times. Times his joy grams HuanShiPian (astrazeneca pharmaceutical Co., LTD production, enterprise H32025391) 1.25 mg. being sponsored by:, daily 1 times; MiPian (Shanghai diaminofurazan plug from zhaohui pharmaceutcal Co., production, enterprise 31021074) 20mg. being sponsored by:H, daily 1 times; Spironolactone piece (guangzhou kang and pharmaceutical industry limited company, enterprise, H44023416) 20mg. being sponsored by:once daily; Symptomatic af high-octane heart failure and add land slice. By starch, dextrin placebo and bitter agent, its smell and taste made with traditional Chinese medicine very similar, placebos look and packaging and Chinese unification.The treatment group (Chinese medicine intervention group):the western medicine foundation treatment+(zhenwu tonga taste) Chinese medicine (every time an agent, treatmentresult 200ml water decocting, morning and evening each, 4 weeks for a period of treatment, continuous three treatment.)Traditional Chinese medicine prescription composition and dosage forms: ripe 15g, tuckahoe aconite 15g, donnell 10g, white atractylodes 10g, ginger 9g, danshen 10g, notoginseng 10g.Clinical observation:record the patient's symptoms, signs change, weekly record 1 times, according to relevant questionnaire syndromes score; Judge cardiac grading change; For heart failure score, Minnesota quality of life questionnaire survey points.Physical examination:each test 1 times before and after treatment. Nerve hormone system index:renin activity (PRA), angiotensin I (Ang I), aldosterone (ALD), b-type natriuretic peptide (BNP); Key indicators - left entricular end-diastolic diameter (LVDs), left ventricular systolic late LVDd), inner diameter (left ventricular ejection fraction (LVEF) using universal GE-7 type ViVid color doppler echocardiographic instrument measurement. Safety index:liver and kidney function, blood, urine, and the routine.2. clinical observation ended, using SPSS statistical analysis, relevant 13.0 with linear regression analysis.Results1. the statistical analysis, two sets of patients generally material including gender, age, before treatment sickness integral, Lee him self TCM's heart failure integral, the quality of life, integration and seere, liver and kidney function etc safety index, difference was statistically significant, comparable. 2. the two groups after treating symptoms were all have improved, compared with before treatment are statistically significant (P<0.05). The treatment group than in control group, the symptoms improve degree was statistically significant (P<0.05). The syndrome integral reduce into P 70 percent,<70% two parts comparison, the therapeutic effect of the treatment group was better than control, a statistically significant difference (P<0.05).3. physical examination:after therapy, two groups of neural hormone system indexes fell, two groups of echocardiographic indexes improved compared with before treatment, are statistically significant (P<0.05). The treatment group index of neural hormone decline level, the system of ultrasonic index improved level heart than control group, there are statistically significant (P<0.05).4. Safety index check:two groups before and after treatment were not significantly change, ALT was not statistically significant (P>0.05), the treatment group:BUN, Cr after treatment with more before treatment group dropped after treatment, compared to decline, also are statistically significant difference (P<0.05).Conclusion:1. zhenwu tonga flavour based treatment and western medicine combined western medicine treatment for Yang based generic chronic heart failure patients water of symptoms, and raising all have effect the quality of life of the patients.2. zhenwu tonga flavour based treatment and western medicine combined western medicine based on Yang generic type water treatment of chronic heart failure myocardial reconstruction are related factors and changes of myocardial benign trend are improved. Reconstruction3. Zhenwu tonga flavour based on joint western medicine treatment group shows the water generics chronic heart failure patients for clinical symptoms improve, improve the quality of survival and myocardial reconstruction improve significantly better than pure western foundation treatment group.4. Zhenwu tonga flavour can improve Yang generic chronic heart failure patients water of renal function.
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