Association Of Blood Serum Bilirubin Level And Coronary Heart Disease In Female

Objectives To study the relationship between blood serum bilirubin levels and coronary heart disease in female patients of coronary artery disease (CHD).Methods According to the results of coronary artery angiography (CAG), 109 female patients were classified to CHD group (n=74) and non-CHD group (n=35). Serum bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL) and indirect bilirubin (IBIL), total cholesterol (TCH), triglyceride (TG) and fasting blood sugar (FBS) levels were measured in all patients. The severity of coronary diseases were evaluated by CCS scores.Results The levels of TBIL, DBIL and IBIL in non-CHD group were significantly higher compared with CHD group (P<0.01). Line correlation analysis showed that TCH (r =-0.398; p <0.05) and TG (r = -0.405; p <0.05) were negatively correlated with serum direct bilirubin levels. There were no relationship between serum bilirubin levels and CCS scores. Multivariable logistic regression analyses revealed a significant independent relation between IBIL (OR 0.666, 95%CI 0.535 to 0.829, P<0.001) , FBS (OR 1.442, 95%CI 1.026 to 2.028, P=0.035) levels and the presence of CHD.Conclusions The low serum direct bilirubin levels may be an independent risk factor of coronary artery disease.