| Objective:To analyze the incidence of malignant lymphoma (ML) in our hospital from 1980-2009 and characteristics of gender and age. To get acquaint with the incidence of different type and stage of malignant lymphoma. Based on verifiable data, an analysis is given about the relevant factors as well, reflecting the change in incidence of malignant lymphoma in order to provide scientific basis for the prevention and treatment of malignant lymphoma in Dalian.Methods:The clinical data of inpatients diagnosed suffering from malignant lymphoma in our hospital from 1980 to 2009 was collected into electronic form for statistical analysis. All these cases were divided into 6 groups in sequence of time, each group with cases of continuous 4 years. A 1:1 matched case-control study was carried out with 60 cases and 60 controls. Data was analyzed with logistic regression.Results:1.6286 cases with hematological disease were diagnosed from 1980 to 2009, the number of malignant lymphoma was 439(6.41% of all), the case of patients increased gradually; total number of 21 patients hospitalized from 1980 to 1983, and the number increased to 193 in years 2005-2009, increased 9.19 times, the average growth rate was 44.73%, with the trend test, the result was statistical significance (P<0.05). Of all the ML, Hodgkin lymphoma (HL) accounted for 15.71%, non-Hodgkin lymphoma (NHL) accounted 84.28%, the average growth rate of HL in every four years was 21.18%, but there was no significant statistical difference (P>0.05), and the average growth rate of NHL in every four years was 50.45%, the result was statistical significance (P<0.05). The number of male and female incidence ratio was 1.87:1, HL peak age of onset was 20 years old to 30 years old, and NHL peak age of onset was 50 years old to 60 years old. Farmers (33.49%) and workers (38.27%) had higher proportion rate of incidence of ML.2. NHL hospitalized patients with pathological type was diffuse large B-cell lymphoma (37.57%), followed by follicular lymphoma (14.05%). The most common pathological type of HL mainly was mixed cell type (33.33%), followed by nodular sclerosis type (21.74%). Compared clinical stage of inpatients, majority of patient with HL were found to have most common stageâ…¡andâ…¢, and in NHL patients, stage IV was most common.3. With the single and multivariate factor analysis, organisms exposed (OR=3.18), family cancer history (OR=1.93), smoking (OR=1.77), surgical history (OR=0.42) were related to ML.Conclusions:1. The number of malignant lymphoma hospitalized cases in 30 years gradually increased. NHL incidence increased significantly, but HL showed a trend of slow growth.2. Patients suffering from NHL were more frequent than HL, more men are affected than women, farmers and workers with ML more than the other occupations. ML showed a single peak age of onset pattern, NHL peak age of onset was 50 years old to 60 years old, and the peak age of HL was 20 years old to 30 years old.3. The pathological type of NHL hospitalized patients was mainly diffuse large B-cell lymphoma, followed by follicular lymphoma. The most common pathological type of HL was mainly mixed cell type, followed by nodular sclerosis type. Compared inpatients with clinical stage, The majority of HL patients had stageâ…¡andâ…¢, and NHL patients stage IV was most common.4. Organics, smoking and family history seem to be associated risk factors of ML, surgical history may be a protective factors.
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