The Epidemiological Characteristics Report Of Malignant Lymphoma: Analysis Of 2,027 Cases In A Single Institution

?Objectives? To estimate the epidemiological characteristics of malignant lymphoma in Hubei,China,and compare the characteristics with other regions in China and western countries,so as to provide a theoretical basis for public health,clinical and basic research.?Methods? A retrospective analysis of 2027 newly diagnosed maliglant lymphoma samples collected from Union Hospital,Tongji Medical College,Huazhong University of Science and Technology from April 2009 to April 2014 were conducted,according to the 2008 WHO classification.Epidemiological information including gender,age,stage,primary parts,extranodal involvement areas were analyzed.Data analysis comparing differences between other regions and countrious was done with SAS software version 9.4(SAS Institute Inc,Cary,NC).Comparisions of categorical variables were done using Pearson chi-square test and Fisher exact test.P<0.01 was considered statistically significant.?Results? The median age of all cases was 53 years,while 54 years for non-Hodgkin lymphoma(NHL)and 38 years for Hodgkin lymphoma(HL).Among the total,mature Bcell neoplasms occupied 63.3%,mature T-and NK-cell neoplasms accounted for 19%,precursor lymphoid cell neoplasms made up 4.5%,and HL constituted 8.0%.The most common subtype of NHL was diffuse large B cell lymphoma(41.3%),followed by NK/T cell lymphoma(13.4%),extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue(MALT lymphoma)(8.0%),follicular lymphoma(6.6%),lymphoblastic lymphoma(4.8%)and mantle cell lymphoma(4.0%).Mixed cellularity lymphoma ranked first among classical HL subtypes,and there is no bimodal median age distribution revealed by our study.Most subtypes revealed male predominance while MALT lymphoma showed a slight female predominance.Extranodal lymphomas most frequently involved sinonasal region,gastrointestinal tract.?Conclusions? The distribution of lymphoma subtypes in Hubei of China is similar to that of Asian populations,as well as other regions of China,but distinct from the Western countries.