Study On The Correlation Between Adiponectin And Recurrent Cerebral Infarction

ObjectiveTo investigate plasma adiponectin levels and their relationships with glucose and lipid, fibrinogen in patients with first cerebral infarction and recurrent cerebral infarction and to explore the contribution of adiponectin in the initiation of recurrent ischemic stroke.MethodsThis study included 30 patients with first-ever stroke,30 cases of recurrent cerebral infarction and 30 patients without a history of cerebrovascular disease. Each group was divided into two subgroups,including combined with diabetes and not with. Levels of Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), FBG, Fibrinogen and adiponectin were compared between three groups. All statistical analysis were performed using the Statistical Package for Social Science(SPSS for Windows, Version 13.0).Result1. The proportion of recurrent patients combined with diabetes, high blood pressure was highest among the three groups. Levels of Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and fibrinogen in patients of recurrent cerebral infarction were highest. Level of high-density lipoprotein cholesterol was lowest, and there were no significant difference of the levels of triglyceride between the three groups.2. Level of adiponectin in patients of recurrent cerebral infarction was the lowest among the three groups.3. Level of adiponectin in diabetic patients was significantly lower than patients without diabetes mellitus. While there was no significant difference between patients with diabetes mellitus.4. Plasma adiponectin concentraion was not correlated to gender.5. The adiponectin level was negatively and significantly correlated with TC, TG, LDL-C, FPG and Fibrinogen, and was positively and significantly correlated with HDL-C.Conclusion1. Adiponectin was closely correlated to recurrent ischemic stroke. Low serum adiponectin levels is an important mechanism in recurrent ischemic stroke.2. Adiponectin may contribute to recurrent ischemic stroke by participating in glucose and lipid metabolism.