Association Of Serum IGF-1 Level With Neurologic Impairment And Clinical Prognosis In Type 2 Diabetes Mellitus Patients Complicated With Acute Cerebral Infarction

Objective The experiment investigate the relationship of IGF-1 with neurologic impairment and clinical prognosis in type 2 diabetes mellitus patients complicated with acute cerebral infarction.Methods The patients from department of Neurology of the First Affiliated Hospital of Xin Jiang Shi he zi University Medical College were divided into 32 cases T2 DM patients complicated with ACI as observed group, and 33 ACI patients without T2 DM, 33 T2 DM patients, and 30 healthy volunteers as control groups.Levels of serum IGF-1 were measured by Enzyme Linked Immunosorbent Assay(ELISA),to compare the difference of IGF-1 on the 3rd and 14 th days among these four groups, and All the ACI patients were assessed neurologic impairment degree by the National Institutes of Health Stroke Scale(NIHSS) score, and evaluated the prognosis by Modified Rankin Scale(MRS) on the 90 th day. By correlation analysis, to research the relationship between IGF-1 and NIHSS and MRS score.Results(1)The IGF-1 levels on the 3rd and 14 th days were lowest in ACI+T2DM group((88.08±24.22),(114.43±24.54)ug/L), followed by ACI group and T2 DM group((99.73±20.25),(125.89±20.35)ug/L;(106.45±19.29),(127.14±19.11)ug/L), and healthy control group((152.50±28.56),(152.56±26.40)ug/L) in turns(p<0.01). The IGF-1 levels of both of ACI group and T2 DM were lower than healthy control group(p<0.05); There were no significant differences between ACI group and T2 DM group(p>0.05).(2)The NIHSS scores on the 3rd and 14 th days were significantly higher in ACI+T2DM group(7.44±2.34,4.34±1.86) than those in ACI group(5.48±1.87, 2.61±1.87)(p<0.05).(3)NIHSS scores on the 3rd and 14 th days were significantly negatively correlated with IGF-1 levels in ACI+T2DM group(r=-0.934, p<0.01;r=-0.821, p<0.01) and ACI group(r=-0.807, p<0.01; r=-0.653, p<0.01). The MRS scores were negatively correlated with IGF-1 levels on the 3rd and 14 th days in ACI+T2DM group(r=-0.309, p<0.05; r=-0.306,p<0.05) and ACI group(r=-0.308, p<0.05; r=-0.369, p<0.05).Conclusion The serum IGF-1 level in ACI patients complicated with T2 DM can be used to evaluate the severity of disease and predict the prognosis.