The Expression And Clinical Significance Of FHIT And Survivin In Human Ovarian Serous Tumor

Objective:Ovarian tumor leads to the highest mortality in the malignan gynecologic disease. Recent data has shown that survivin, an inhibitors of apoptosis, known as the strongest death inhibit gene, is called live element. FHIT, which induces apoptosis and inhibits proliferation of tumor cells, has been known as tumor suppressor gene. Decrease of FHIT gene expression plays an important role in occurrence of many tumors.There are opposite biology effects between FHIT and survivin. Although both of them took part in cell cycle control and apoptosis, their functions in ovary tumor and correlations remain unclear.To elucidate role of survivin and FHIT in apoptosis and proliferation of ovary tumor, we examined their protein expressions in ovarian serous cystadenoma, ovarian borderline serous cystadenoma, ovarian serous cystadenoc_rcinoma, and discussed their role in ovarian tumor cell apoptosis and proliferation, furthermore estimated their potential value as biomarker for early diagnosis of ovarian tumors and prognostic.Methods:Protein expressions of survivin and FHIT in 24 cases of ovarian serous cystadenocarcinoma,14 cases of ovarian borderline serous cystadenoma and 20 cases of ovarian serous cystadenoma were detected using S-P immunohistochemical technique.Results:The positive rates of survivin in 24 cases of ovarian serous cystadenocarcinoma,14 cases of ovarian borderline serous cystadenoma and in 20 cases of ovarian serous cystadenoma were 79.2%,71.4%,30.0%, respectively; FHIT were 55% 85.7% and 90%, respectively. The positive expression rate of survivin in ovarian serous cystadenocarcinoma and ovarian borderline serous cystadenoma was significantly higher than that in ovarian serous cystadenoma. (p< 0.05).The degree of expression of survivin has significant relationship with clinical stage, tissue classification, etc. The positive rate of FHIT in ovarian serous cystadenocarcinoma tissue was significant lower than that in ovarian serous cystadenoma and ovarian borderline serous cystadenoma (p< 0.05). With the development of tumor, the protein expression of survivin was upregulated, while FHIT was downregulated at meantime.Conclusions:Survivin was over expressed in ovarian serous cystadenocarcinoma. The protein expression of FHIT was downregulated and losely related to the expression of survivin.Both of survivin and FHIT participated occurrence and development of ovarian serous cystadenocarcinoma.(1) There was close relation between the clinic pathogenesis chara-cters of ovarian serous cystadenocarcinoma with survivin and FHIT protein expression.(2) Our results showed that survivin and FHIT gene eapression is related to pathologic degreee, clinical stages and grognostic. Combinational detection of survivin and FHIT protein expressions imply a important value for diagnose for ovarian serous cystadenocarcinoma, indicating the malign-nant degree of the tumor and prognosis.