| Objective:Condyloma acuminatum(CA) is the common sexually transmitted disease in clinical, and there is a gradual upward trend, recent studies have shown that HPV infection.or genital condyloma may cause or secondary malignancies such as cervical, vulvar, anal cancer, and so on, which led to a high degree of human attention。It is very easy for CA to recurrent attacke, The method of Chinese medicine topical treatment of condyloma have been reported for many times which make little effect, it is becoming an isue to find an ideal method of chinese herbal for CA. in the professin of TCM. This research is to study the efficiency of YOUKELUO which is an chinese hebal medicine,according to observe the efficiency and laboratory indicators for comparison of youkeluo and C02 laser for CA, the aim of the study is to find an ideal, safe and convenient chinese patent medicinefor CA.Method:A prospective randomized controlled study is used in the research,132 cases of condyloma cases which meet the inclusion criteria will be divided into treatment group 65 cases of Youke Luo and laser control group,67 cases, respectively in accordance with research program for treatment. two sets of indicators and data before and after the treatment will be Collectted which including general informations, clinical effects, the days of the the surface of wound healing, the rate of the clearance of the virus, the rate of the recurrence, the safety, the untoward effect and so on。The softwareof spssl7 is used to analysis the date, Chi-square test is used to analysis the results of treatmentResults: 1.general informations:there is no statistical significance in the comparision of the age, the degree of education, the course of disease and the number of the warts.2. Comparison of the efficacy of the two groups:in treatment group, there were 65 cases of traditional chinese medicine "Youkeluo", All the warts of which were removed, The rate of elimination was 100%; laser-control group,67 cases, the virus removal rate is also 100%. There is no significant difference between the two groups (P>0.05).3. Comparison of HPV-DNA-PCR results of the two groups:(1) HPV-DNA-PCR results of the inspection:excellent Luo treated 59 cases can be negative in 32 cases,27 cases were positive and negative rate was 54.24%; laser group 63 cases, negative 21 cases,42 cases of positive and negative rate was 33.33%. Using chi-square test P=0.020, difference between two groups of viral clearance rate was statistically significant (P<0.05).(2)HPV-DNA-PCR results of the inspection:treatment groups:41 cases were negative,18 cases were positive and negative rate was 77.97%;laser group:negative 25 cases,38 cases of positive and negative rate was 39.68%. difference between two groups of viral clearance rate was statistically significant (P<0.05).(3)HPV-DNA-PCR results of the inspection:excellent Luo treated 59 cases can be negative in 46cases,13 cases of positive and negative rate was 69.49%; laser group:negative 28 cases, positive in 35 cases, negative rate was 44.44%. Difference between two groups of viral clearance rate was statistically significant (P<0.05).4. Comparison of relapse rate of the two groups:(1)1 month after treatment,4 cases recurrenced in the treatment, the recurrence rate was 6.78%. in control group 1 month after treatment 14 cases of recurrence, the recurrence rate was 22.22%,,1 month after treatment two groups compared the recurrence rate, the difference was statistically significant (P<0.05).(2) 3 months after treatment, in the treatment group 4 case recurrenced, the recurrence rate was 6.78%, in the control group18 cases recurrenced 3 months after treatment, the recurrence rate was28.57%, in the two groups 3 months after treatment, difference in recurrence rate statistically significant (P<0.05). (3)6 months after treatment,4 cases recurrenced in the treatment group, the recurrence rate was6.78%.20 cases recurrenced 6 months after treatment in the control group, the recurrence rate was 31.75%, in the two groups 6 months after treatment, difference in recurrence rate statistically significant (P<0.05). Conclusiongs:Youkeluo can remove the lesion of CA, which can be compared with the efficiency of the C02 laser, however the rate of the repelling the HPV, the rate of the recurrence are better than the C02 laser. The clinical efficacy of YOUKELUO is lclear, the side effect and untoward effect are slight. YOUKELUO is confirmed to be a great prospect for the development of Chinese medicine for external use.
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