| ObjectiveCondyloma acuminatum(CA) is one of the common sexually transmitted disease in clinical, and there is a gradual upward trend recently, secondly it may cause cancer such as cervical cancer, Squamous cell carcinoma and so on, which led to a high degree of human attention. There are many traditional topical drugs which are used on treatment of Condyloma acuminatum in clinical,but the mechanism of them are usually unkonwn. If we kown the mechanism, it will be useful for the treatment of Condyloma acuminatum. This research is to study the possible mechanism of "youkeluo" in cell biology.MethodThe expression of Mcm2, Caspase-3of epidemic cells of17female cases of CA were detected by SP immunohistochemicel technique. Cell apoptosis index was determinated by TUNEL method. The softwareof spss17will be used to analysis the data.Results17female patients were treatd by youkeluo:the cell proliferating index labelig in Mcm2before treatment was55.35±14.41, and after treatment it was16.06±14.10, there was statistical significance(z=-3.623a, P<0.01); the expression of Caspase-3was6.12±2.93before treatment, and after treatment it was10.88±1.88, which was higher than that before, there was statistical signif icance(t=2.368, P<0.01); the cell apoptosis index laheling in TUNEL before treatment was18.12±9.77, and after treatment it was27.82±15.19, which was higher than that before, there was statistical significance (z=-1.967a, P<0.05).ConclusionThe effectidve mechanism of youtuoxin may take effect through inlibiting cell proliferating and promote cell apoptosis. |
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