Research On The Curative Effect Of Jianpi Hewei Treatment For Atrophic Gastritis And The Expression Of COX-1,COX-2,Ki-67,GST-π

Objective By investigating the clinical effect and the indication of COX-1,COX-2,Ki-67,GST-πon gastric mucosa treated by jianpi hewei treatment,in order to explore the mechanism of this treatment.Methods 30 atrophic gastritis patients of clinical diagnosis by endoscope werecollected as a study group,basing on jianpi hewei treatment,cured byLiujunzi decoction,modified with symptoms.6 months were taken as acourse of treatment.After a course of medication in general,took gastr oscopy again.Observethe improvement in clinical symptoms,the mucosarepresentation in gastroscope,pathology and the expression of COX-1,COX-2,Ki-67,GST-πin immunohistochemical examination.Results Clinical observation indicates that jianpi hewei treatment for atrophic gastritis has significantly effect on clinical symptoms,the mucosa representation in gastroscope and pathology.The notable effective rate on curative effect was 86.2%.Immunohistochemical results show that the expression of COX-1,COX-2,Ki-67 protein has significantly difference after treatment(P＜0.01).GST-πprotein expression has no significantdifference(P＞0.05).There is the positive correlation between COX-2,Ki-67 protein expression and the extent of the disease,the negative correlation between COX-1 and the extent of the disease(P＜0.01).GST-πprotein expression had no correlation with the extent of thedisease(P＞0.05).Conclusion According to the analysis,jianpi hewei treatment can not only ameliorate clinical symptom,but also reverse pathologic status of atrophic gastritis and precancerous lesions effectively,at the same time reveal the intervention of Chinese medicine helps to improve the status of cell prolifera-tion,prevents the further development of this disease.According to jianpi hewei and differential treatment as the guiding ideology and characteristic.This treatment plays an integral regulation role.The effect is significant.So it is an effective way for the treatment of chronic atrophic gastritis.