The Observation Of Clinical Effects Of Tougusan Fumigation Therapy On Patients With Deficiency Of Both Qi And Yin With Blood Stasis And Diabetic Peripheral Polyneuropathy

Objectives: Observing the clinic symptom assessment, tip thermesthesia changes, and vibration perception threshold (VPT) of Tougusan fumigate on therapy on the patients with deficiency of both Qi and Yin with blood stasis and diabetic peripheral neuropathy (DPN); evaluating the clinical effects and security of Tougusan fumigation therapy in treating deficiency of both Qi and Yin with blood stasis and DPN; researching the mechanism of Tougusan fumigation therapy.Method: Subjects were chosen based on the diagnosis standards of diabetes and DPN. Sixty subjects were randomly divided into the Experimental Group and Control Group, both of which were under the basic diabetic treatment and provided with mecobalamine. The Experimental Group was treated with Tougusan fumigating lower limbs (30 minutes each time, once each day). The Control Group were fumigated with warm water. In eight weeks of treatment, data of major DPN symptom scores, Michigan Neu-ropathy Screening Instrument (MNSI) scores, traditional Chinese medical symptom-type scores, 10g monofilament, thermesthesia, algesthesia, VPT were collected and analyzed. SPSS 17.0 was employed to conduct the statistic analyses of the effects of of Tougusan fumigation therapy on patients with deficiency of both Qi and Yin with blood stasis and DPN.Results: (1) traditional Chinese medical symptom-type scores: Significant improvementswere found in both the Experimental Group and the Control Group (P<0.05), and even greater effects were found in the Experimental Group with the significant difference between the two groups (P<0.05); (2) major DPN symptom scores: Improved DPN symptoms were found in both groups, and the Experimental Group outperformed the Control Group. Significant improvements were found in limb numbness, limb weakness symptoms , local ague symptom and muscular spasms with the Experimental Group (at the significant level of .05 and .01 respectively), while with the Control Group, significant improvement was found in limb numbness and limb weakness symptom (at the significant level of .01); (3) MNSI scores: Significant improvements were found in both groups, and the Experimental Group outperformed the Control Group (p<0.01); (4) Regarding VPT scores,after treatment both groups exhibited better results than before ,but the difference was not statistically significant; Regarding the 10g monofilament examination, the Experimental Group exhibited better results than the Control group; Regarding the thermesthesia and algesthesia examination, the Experimental Group showed slightly better results than the Control Group, but the difference was not statistically significant. Conclusion: Other than the basic diabetic treatment, Tougusan fumigation therapy can significantly improve the clinic symptoms and simple screening indexes of DPN patients. Some indexes outperformed those of the Western medical and warm water fumigation treatments, indicating that Tougusan fumigation therapy may improve the blood circulation of the lower limbs and facilitate the recovery of the impaired nerves of the DPN patients, hence serving as a desirable supplementary therapy for treating DPN.