Study On The Correlation Between Visfatin, Adiponectin And Acute Cerebral Infarction

ObjectiveTo investigate plasma visfatin and adiponectin levels and their relationships to neurological function deficits, insulin resistance, C-reactive protein (CRP), glucose and lipid metabolism in patients with acute cerebral infarction and to explore the contribution of them in the initiation of acute cerebral infarction.MethodsThe study was designed in the first hospital affiliated to Soochow University between February 2008 and January 2009. Forty-eight patients with cerebral infarction were divided into two groups according to the blood pressure, 24 patients with hypertension and 24 patients without hypertension. 40 subjects matched by age and gender who made health examination in the hospital served as controls: 20 subjects with hypertension and 20 healthy subjects who were in the normal controls. After overnightfasting, a single blood sample was obtained. Plasma adiponectin, visfatin and fasting insulin were measured by enzyme linked immunosorbent assay (ELISA), whereas fasting plasma glucose (FPG), triglycerides, total cholesterol, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), CRP and prealbumin were measured by automatic biochemistry analyzer and at the same time, height, weight,waistline,hip circumference and blood pressure were measured and patients with cerebral infarction were evaluated the neurological function with the National Institutes of Health Stroke Scale (NIHSS) and then the body mass index (BMI) and the waist-to-hip ratio (WHR) and the Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) were calculated. All statistical analysis were performed using the Statistical Package for Social Science(SPSS for Windows, Version 13.0).Results1. Plasma visfatin, FPG, CRP, HOMA-IR and fasting insulin were significantly higher in hypertensive cerebral infarcted group and simple-cerebral infarcted group compared to the simple-hypertensive group and the normal controls (P<0.05). The HOMA-IR and fasting insulin level were significantly higher in the simple-hypertensive group compared to the normal controls (P<0.05).2. Compared to the normal controls, plasma adiponectin, HDL-C, and prealbumin were significantly lower and triglycerides was significantly higher in the other three groups (P<0.05).3. Both cerebral infarction and hypertension have effects on adiponectin, and they may interact with each other, however, the visfatin level only be affected by cerebral infarction.4. The visfatin level was positively and significantly correlated with WHR, LDL-C, CRP, FPG, HOMA-IR and fasting insulin in patients with acute cerebral infarction.5. The adiponectin level was negatively and significantly correlated with NIHSS, BMI, WHR, CRP, HOMA-IR, FPG and triglycerides, and was positively and significantly correlated with HDL-C in patients with acute cerebral infarction.6. In multiple regression analysis, HOMA-IR and LDL-C were independently associated with visfatin, whereas HOMA-IR, CRP and triglycerides were independently associated with adiponectin.Conclusions1. The visfatin level was increased and the adiponectin level was decreased in patients with acute cerebral infarction, the adiponectin level was also correlated with the neurological function deficit extent.2. Visfatin and adiponectin may contribute to the initiation of cerebral infarction by participating in insulin resistance, glucose and lipid metabolism, atherosclerosis and inflammation.