Mechanism Of Prescription Of Enriching Kidney And Assisting Pregnancy In Treating Luteal Phase Defect

Objective: To observe the clinical efficiency of prescription of enriching kidney and assisting pregnancy on luteal phase defect and establish a luteal phase defect rat model to investigate the mechanism of the treatment on one of the pathogeny aspects.Methods: On clinic the 36 patients according with the diagnosis standards have been treated by the prescription for 3 months,then compare the different sex hormones levels with that before the treatment and observe the vary of the basal body temperature(BBT), and the level of cytoimmunity.In the animal experiment, the model was formed by mifepristone that can lead to luteal phase defect. The rats were randomly divided into 3 groups,that is the control group. the model group and the herbs group: the control group / NS( normal control) the model group / NS+ mifepristonethe herbs group/ Prescription of enriching kidney and assisting pregnancy+ mifepristoneTwenty hours after estrus of the 4th sex periods, kill all the rats.Serum was separated and the method of chemiluminescence was applied to test E2,P,and LH.The sample of one side of ovary and uterus was left for pathological examination.The sample of another side of ovary was observed by electron microscopic.Results: Prescription of enriching kidney and assisting pregnancy can improve paticents' menstruation and common syndromes, improve the hign-temperarure of BBT, and regulate both sex hormone(LH,P)and cytoimmunity effectively. Prescription of enriching kidney and assisting pregnancy can improve both the development of endometriun and the development of gland as well.It can promote the increasing of ovary Luteal phase cells,improving the structure of Luteal phase cells to strengthen the function of Luteal phase.