Experimental Study On The Treatment Of Perimenopausal Syndrome With Meishen Capsule

Objective To explore the effects of Meishen capsule on serous sexual hormone, monoamine neurotransmitter content of hypothalamus and blood-lipid,anti-oxygen index in ovariectomized rats.Methods Using ovariectomized rats as model and Gengnianxin capsule as positive control drug,The change of serous sexual hormone,monoamine neurotransmitter content of hypothalamus at 4w after intervening with Meishen capsule,the change of bodyweight and the contents of blood-lipid(BL),anti-oxygen index after 12w were obversed in ovariectomized rats.Results Compared with model group,Meishen capsule could obviously increase the content of Estradiol(E2) and decrease that of Follicl-stimula ting Hormone(FSH), Luteinizing Hormone(LH).In addition,the prescription could also effectively decrease the index of 5-hydroxytrypta mine(5-HT),5-hydroxyindole acetic acid(5-HIAA) and increase that of norepinephrine(NE) and dopamine(DA).Every dosage group of Meishen capsule could decrease the weight of rats,especially the high and middle group.The values of total cholesterol(TC),low density lipoprotein cholesterol(LDL-C) in both high and middle dosage group could decrease,the content of high density lipoprotein cholesterol(HDL-C) in the former group also could increase,the values of TC in the low dosage group could decrease.The activity of superoxide dismutase(SOD) both in high and middle dosage group could increase,in which the contents of Maleic Dialdehyde (MDA)could decrease.Compared with the three groups,there was a significant difference.Conclusion Meishen capsule could stabilize organism internal environment and relieve the perimenopausal symptoms by accommodating cryptorrheic and nervous system of ovariectomized rats.It also can accommodate confused blood-lipid of ovariectomized rats,which indicate that it could prevent the patients from getting atherosclerosis or coronary artery disease(CHD) and treat the syndrome.