Association Between Natriuretic Peptide Precursor A Gene Polymorphism And Coronary Heart Disease In Chinese Han Population

Background: The Natriuretic peptide precursor A (NPPA) is synthesized, stored, and released by atrial myocytes, previous studies have shown that NPPA plays a significant role in coronary circulation regulation and in atherosclerosis. rs5065 NPPA gene polymorphism leads to the translation of NPPA with two additional arginines, and has been suggested to be associated with salt-sensitive hypertension.The purpose of the present study was to investigate the relationship between the rs5065 NPPA gene polymorphism and the risk of coronary heart disease (CHD) in Chinese Han population.Method: We genotyped the SNP (Single nucleotide polymorphism) rs5065 NPPA in the human NPPA gene in1861 subjects sex-and age-matched comprising of 904 CHD Cases and 957 Controls of Chinese Han population. Genotyping of SNP was performed with Taqman SNP allelic discrimination assays by means of an ABI 7900HT. The levels of fasting serum total cholesterol (TC), triglycerides (TG), and fasting plasma glucose (FPG) were determined. Weight, height, and BP were measured and BMI was calculated.Result: Our study showed that the frequencies of rs5065 NPPA C allele in the case and the control groups were 0.012 and 0.005 respectively. There was significant difference in C allele frequency distribution between the two groups (OR=2.607, 95% CI: 1.197-5.678, P=0.012). There was significant difference between rs5065 NPPA polymorphism and smoking status in cases P=0.037, and no significant difference between Gender, Age, Fasting total cholesterol (TC), triglycerides (TG), fasting plasma glucose (FPG), body mass index (BMI), and Systolic blood pressure (SBP) P >0.05.Conclusion: Our results suggest that the C allele of rs5065 NPPA polymorphism may be associated with the risk of CHD.