| Objective: Anterior uveitis is a inflammatory disease which is involved iris and ciliary. it is a common and leading blinding ocular diseases. According to the understanding on the etiology and pathogenesis of Anterior uveitis, professor Qinxingrui said the main type of anterior uveitis is wind-heat type of liver meridian, so the chief treating method is heat-clearing and dispelling wind, cooling blood and detoxifying, so she created Qingmu Decoction to treat anterior uveitis. In this topic, the effects of Qingmu Decoction were verified by observing sixty patients, explore its mechanism and the reason of reducing recurrence.Methods: After the building of clinical standard, sixty patients were choosed and randomly divided into the treatment group and the contrast group. The treatment group were given Qingmu Decoction combining with eye drops therapy, and control group were given indomethacin combining with eye drops therapy. After the treatment, comparing the curative effects, the therapeutic efficiency of TCM symptoms, visual acuity, the main symptoms and physical sign, immunoglobulin and complement and the average healing time.Results:①With the standard of clinical curative effects: in the treating group, 11 were cured, 12 had obvious effects, 5 had effects and 2 had no effects. The total effective rate was 93.33%. in the contrast group, 8 were cured, 13 had obvious effects, 6 had effects and 3 had no effect. The total effective rate was 90.00%. In comparision there is no significant difference between two groups (P>0.05), which demonstrates the treatment effectiveness between the treating group and the contrast group is similar.②With the standard of curative effects in the TCM: in the treating group, 21 were cured, 6 had obvious effects, 5 had effects and 1 had no effect. The total effective rate was 96.67%. in the contrast group, 16 were cured, 9 had obvious effects, 3 had effects and 2 had no effect. The total effective rate was 93.33%. There is no significant difference between the two groups by statistical comparison (P>0.05), which demonstrates that the treatment effectiveness between the treating group and the contrast group is similar.③In both treating and contrast groups, there is statistical difference in the comparison of visual acuities before and after treatment (P<0.05), which demonstrates that after the treatment, the patients in the both groups had significantly improved their visual acuities. However, since after the treatment there is no significant difference between the two groups (P>0.05), it demonstrates that there is no difference for the treating group and the contrast group in improving visual acuities.④In the aspect of usual symptom disappearance and relief rate, after the treatment there is no significant difference in symptoms and physical characteristics between the two groups (P>0.05), which demonstrates that the treating group has the same effects as the contrast group on improving the symptoms, such as eye-ache, photophobia, tearing and ciliary congestion, etc. Before and after the treatment, there is significant difference symptoms and physical characteristics between the two groups in (P<0.05), which demonstrates that after the treatment the symptoms and physical characteristics in both treating and contrast groups had been significantly improved, and indicates that both Qingmu Decoction and indomethacin can effectively improve the clinical symptoms and physical characteristics and relieve the pains of patients.⑤Before and after the treatment, there is statistical difference in IgG comparison of the treating group (P<0.05); before and after the treatment, there is statistical difference in IgG comparison of the contrast group (P<0.05); before and after the treatment, there is statistical difference in IgA comparison of the treating group (P<0.05); before and after the treatment, there is statistical difference in IgA comparison of the contrast group (P<0.05). These demonstrate that after the treatment the immunity of the patients in the two groups had been improved to different degree. Before and after the treatment, there is statistical difference in IgM comparison of the treating group (P<0.05); before and after the treatment, there is no statistical difference in IgM comparison of the contrast group (P>0.05), which demonstrates that after the treatment the immunity of the patients in the treating group had been improved, but no significant improvement occurred in the contrast group. By statistical analysis, after the treatment there is significant difference in IgG and IgA comparison of the two groups (P<0.05), which demonstrates that after the treatment, the improvement of the patient immunity in the treating group was better than that in the contrast group. There is no statistical difference in IgM comparison of the two groups after the treatment (P>0.05).⑥Before and after the treatment, there is statistical difference in C3 comparison of the treating group (P<0.05); before and after the treatment, there is statistical difference in C3 comparison of the contrast group (P<0.05), which demonstrates that after the treatment the immunity of the patients in the two groups had been significantly improved. Before and after the treatment, there is statistical difference in C4 comparison of the treating group (P<0.05); before and after the treatment, there is no statistical difference in C4 comparison of the contrast group (P>0.05), which demonstrates that after the treatment the immunity of the patients in the treating groups had been improved, but in the contrast group there is no significant improvement. After the treatment, there is significant difference in C3 comparison of the two groups (P<0.05), which demonstrates that after the treatment the improvement of the patient immunity in the treating group was better than that in the contrast group. There is no statistical difference in C4 comparison of the two groups after the treatment (P>0.05).⑦By statistical analysis, there is significant difference in the total clinical cure days in the two groups (P<0.05). The cure days in the treating group are greatly less than the contrast group, which demonstrates that Qingmu Decoction can effectively reduce the clinical course, and speed up diminishing inflammation.⑧As one year of follow-up survey, in the treating group, 11 cases and 13 eyes had been cured out of 30 cases; no any case reoccurred, and the reoccurrence rate is 0. In the contrast group, 8 cases and 8 eyes had been cured, and 4 cases reoccurred out of 30 cases; the reoccurrence rate is 37.50%. The reoccurrence rate in the treating group is much lower than the contrast group. By statistical analysis, there is significant difference between the treating group and the contrast group (P<0.05), which demonstrates that Qingmu Decoction can effectively lower the reoccurrence of this disease.Conclusion:①Qingmu Decoction has showed obvious clinical effects to wind-heat type of liver meridian in anterior uveitis, it could relief symptoms effectively and attenuate inflammation, the clinical effects were equal to the control group.②Qingmu Decoction could reduce the patients'immunoglobulin and complement significantly, it was suggested that Qingmu Decoction has good effects of anti-inflammation and immunoregulation.③The average healing time of the treatment group was much lower than the control group in cured patient of two group, it showed that the Qingmu Decoction was superior to the indomethacin in shorting the course of disease.④The recurrence rate of the treatment group was much lower than the control group in cured patient of two group, it showed that visual acuities has a great advantage in preventing recurrence.⑤No adverse reactions were found during the course of treatment with Qingmu Decoction, it was suggested that Qingmu Decoction is safe without side effects.
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