| Objective: The acute catarrh conjunctivitis is the clinical common disease, often infects popularly, which have seriously affected people's lives, work, study. How to quickly cure the disease, in order to control its infection to be popular, is a clinical attention matter. Through observation on patiens and experiment on rats, the theme try to testify the effects of Qingmutang, and explain the work pattern of Qingmutang. Partâ… The clinical study on wind heat acute catarrhal conjunctivitis with QingmutangMethods: after the building of clinical standard, 72 patients were choosed and randomly divided into two groups: the treatment group and the control group. There are no statistics significances between the two groups of the general situation. Patiens in the treatment group drunk Qingmutang 200ml, 2 times every day. Patiens in the control group drop levofloxacin eyedrops, each one drop, 4 times every day. There are 14 days in the course of treatment. In the period, patients stop taking the drug which affecting the acute catarrhal conjunctivitis.Results:1 Compared with the effect of every group before and after treatment There are a obvious curative effect before and after treatment. There are statistics significance between before and after treatment (P <0.05).2 Compared with the effect between the two groups There are no significant difference between the two groups (P> 0.05).3 Compared with the course of treatment between the two groupsThere are statistical significance between the two groups of the course of treatment, the treatment group course of treatment is shorter than the control group's.Conclusion: The subject has shown that Qingmutang has significant efficacy for wind heat acute catarrhal conjunctivitis; in the course of treatment, the Qingmutang group is shorter than levofloxacin eye drops group.Partâ…¡The experimental study on wind heat acute catarrhal conjunctivitis with QingmutangMethod: we choose 50 Wista rats who are clean and health without diseases of the eye. They were randomly divided into 5 groups, the blank group, the model group, Qingmutang low-dose group, Qingmutang high-dose group, control (levofloxacin eyedrops) group. It is the method to inject the bacteria suspension in rat subconjunctiva and cut the rat conjunctiva for dropping some bacteria suspension. The blank group does not become, the others become the model of acute catarrhal conjunctivitis. The blank Group and the model group have not been treated, the others have been treated. The rats were treated for 14 days continuously. We observed rats general condition and conjunctivitis. After modeling success score and after treatment score once every three days to the rat eye in each group, a total score of five. On the 15th day, we sacrificed all rats and test the level of cd4 and cd8 in their blood, take out the conjunctiva for pathological staining.Results:1 General condition:In the experiment process, rats do not dead, rats are in good health.2 Rats conjunctivitis:After 24 hours, all rats eye become acute catarrhal conjunctivitis, conjunctival hyperemia, edema, and secretions, There are no significant difference among the four groups P>0.05. In the experiment, rats conjunctivitis gradually improved. After the treatment, there are no significant difference among the three groups of treatment P>0.05, it is statistical significance to compared the three groups with the model group P <0.05.3 Flow Cytometry: After the treatment,there are statistical significance between medication groups and the model group. P<0.05, there are no significant difference among medication groups, P>0.05.4 Rats conjunctival histopathology: trere are no anomaly on conjunctiva histological section of the blank group, there are inflammation on conjunctiva histological section of the model group, Qingmutang low-dose group, Qingmutang high-dose group and control group.Conclusion:1 The improved method is successful.2 There are a good curative effect in Qingmutang low-dose group, Qingmutang high-dose group and control group. There are no significant difference among the three groups. It showed that there are the good curative effect about Qingmutang to the animal model.3 Studies have shown that Qingmutang can increase the CD4+T cells and reduce the CD8+T cells. It can increase CD4/CD8 ratio, so for cell-mediated immunity in the proportion of T-lymphocyte subsets with a regulatory role, so that cell-mediated immunity is dominant role, resulting in improved immune function.
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