The Effect On Suppurative Peritonitis Model Rat Of Yellow Saltpetre Oral Liquid On TNF-a, IL-6

Purpose: Nature peritonitis rat observing face to face acute saltpetre sulphur oral liquid TNF-α, IL-6's effect , treating with the nature peritonitis rat appraising face to face acute saltpetre sulphur oral liquid purulence effect.Method: Adopt the Wistar rat 50 to use cecum ligation legal institutions to become necrosis nature cecitis combining to fester nature peritonitis animal model. The random is that five group , blank space contrast a group mark; Taw the yellow oral liquid group; Taw the yellow oral liquid + antibiotic group; Antibiotic group; The regular group , 1,3 day spirit blood observe TNF-α,IL-6 content , 7 day open an abdomen searching abdominal cavity adhesion condition。Result: 1. yellow saltpeter oral liquid can thickness having acute bacterial effect lessening peritonitis rat blood middle TNF-α, IL-6.2. yellow saltpetre oral liquid can reduce the rat death rate obviously , taw yellow oral liquid but effective prevention and cure and restrain inflammation reaction.Conclusion: 1 yellow saltpetre oral liquid can have an effect to reduce the impatient bacterial peritonitis rat blood middle TNF-α, the TNF-α, IL-6 are horizontal and the rat prognosis presents to be being related to in the IL-6 thickness , impatient bacterial peritonitis rat blood. And the effect curing group lessening is obvious better than that model group, the death rate reduces obviously with medicine queen rat. Demonstrate yellow oral liquid of saltpetre may have effect prevention and cure and restrain inflammation reaction further.