Spleen Sedative Effect Efficacy&Mechanism Studies Of Qishan Oral Liquid

Objective: Research pharmacological effect&its principle for the effect of health carespleen&calm the nerves of Qi Shan oral liquid. Study its treatment effect.Method: Apply extending sodium pentobarbital little mice sleeping time experiment,threshold dose of sodium pentobarbital hypnotic experiments in mice, intraperitoneal injectedNikethamide injection induced seizures in mice experiments, locomotors activity in miceexperiments, Observe the sedative effect after applying Qi Shan oral liquid for little mice,Rhubarb decoction with oral gavage induced diarrhea spleen model, model of intraperitonealinjected with reserpine induced mice spleen deficiency, Observe its influence of spleen.Determine content of5-HT,NE and DA in mouse brain after them oral injected Qi Shan oralliquid with applying ELISA method. Discuss sedative mechanism of Qi Shan oral liquid.Result: Qi Shan oral liquid can significantly shorten sodium pentobarbital model micesleep latency, and extend their sleep time, increase sleep rate of mice in the case of applyingsodium pentobarbital of sub threshold dose, increase content of GAS&MOT of spleendeficiency diarrhea model rat, decrease spleen viscera coefficients, decrease Rate of smallintestinal propulsive, increase content of RBC&HGB, can significantly extend the spleendeficiency mice swimming time, can significantly extend Convulsions latency&time ofdeath of mice, decrease normal mice spontaneous number of activities, significantly increasecontent of5-HT in mice brain, decrease content of NE&NA.Conclusion: Qi Shan oral liquid with good effect of health care spleen&calm the nerves.This research also lays foundation for further development of new medicines.