| Objective: in patients with acute suppurative peritonitis Wistar rats caused by animal model of SIRS observing yiqi tong(yellow oral liquid) nitrate under the WBC inflammatory markers of SIRS, TNF- a, IL- 6, the influence of TNF- a R, to evaluate the therapeutic effect of Wistar rats.Methods: 50 male and female and 50 healthy Wistar rats, weight 170 g ~ 190 g, the cecum ligation to ASP animal model.Amount of saline lavage were given model group, Chinese medicine group, yiqi tong under lavage(nitrate yellow oral liquid) group, western medicine group: intraperitoneal injection of cephalosporins pp sodium(western medicine), Chinese and western medicine group in sodium nitrate yellow oral liquid + ketone of cefepime injections pp blank group: don't do disposal, after building randomly drawn from each group of 10, only in 1 day, 2 days, 4 days, 6 days in eye angular blood, in blood were separately measured TNF- a, IL- 6, TNF- a R levels, and the WBC count.Results: yiqi tong(nitrate yellow oral liquid) can effectively reduce the ASP caused by SIRS Wistar rats model, the concentration of serum TNF- a higher TNF- a R, the concentration of IL- 6, the effect of treatment group is better than blank group, model TNF- a systemic inflammatory response syndrome caused by acute suppurative peritonitis and negatively correlated with the prognosis of rats in the model, TNF- a R, IL- 6 level was positively correlated with the prognosis of rats, and the model group after mortality significantly.conclusion: in the treatment of systemic inflammatory response syndrome(yellow oral liquid, can effectively adjust the anti-inflammatory factor and the expression of proinflammatory factor, are of great significance, and the balance of its to participate in the critically ill treatment of traditional Chinese medicine, rich SIRS treatments, maximum protection function lesion organs, tissues, cells, prevent the happening of the MOF to provide experimental evidence... |
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