Level Of Vascular Endothelial Growth Factor In Induced Sputum And Its Implications In Chronic Obstructiv Pulmonary Disease

Chronic obstructive pulmonary disease (COPD) is a disease of the airflow limitation and incompletely reversibility. Its main pathogenesis is the inflammatory and an abnormal balance between proteases and anti-proteases. Vascular endothelial growth factor (VEGF) is group of functions formidable cell factor that have many kinds of effect. By the results of a recent study, in which there was progressive loss of capillary endothelial and alveolar epithelial cells through the process of apoptosis in COPD. But VEGF apopsis in the lung structure cell holds the extremely important status, how does its function and the level occur to COPD develops, but also are not known. This research observes VEGF levels in induced sputum in patient with acute exacerbation COPD , and evaluate the correlations between VEGF level and COPD.This study observe 30 patients with acute exacerbation COPD,16 patients with bronchial asthma, and 17 normal controls were include in the study. The concentration of VEGF in supernatant from patients, which inhaled 3.5% saline by ultrasonic nebulizer was measured using an ELISA. While sputum total cells (TCC) and differential cell were detected by manual method. Result : TCC in COPD group was significantly higher than those in other group (P<0.01),the percentage of neutrophils in COPD group was significantly higher than that in control subject(sP<0.01).The percentage of eosinophils and neutrophils in asthma with acute exacerbation were significantly higher than those in control subjects(P<0.01,P<0.01=⑵.The concentration of VEGF in induced sputum was significantly higher in patients with asthma than in normal controls(P<0.01=,and the concentration of VEGF was significantly lower in patients with AECOPD than in those with asthma or normal controls(P<0.01,P<0.01=,Level of VEGF was lower in patient with COPD stagesⅢthan COPD stagesⅠ,but not significant. There was a negative correlation between the concentration of VEGF in sputum samples and FEV1% in patients with asthma. However, there was a positive correlation between the concentration of VEGF and FEV1% in patients with AECOPD. Conclusion: Levels of VEGF was different between asthma and COPD. Sputum VEGF levels may reflect the different pathologic processes of these two diseases. The decreased levels of VEGF were associated with airflow limitation and alveolar destruction in patients with AECOPD, VEGF may plays the vital role in the pathogenesis of COPD.