A Further Study On Anemia Treatment By BaZhen Decoction

Purpose: At present, there is little research for the changes of hemorheology of anemia, especially there is nothing in clinical research. With the direction of theory of Traditional Chinese Medicine and western medicine, the clinical treatment was in progress, BaZhen decoction and iron treatment group, only iron treatment group, observe the Hb,SI,TIBC and hemorheology, microcirculation, to observe the efficiency of two groups. The purpose is prevented the developing of anemia and provided the foundation for clinical treatment.Methods: By means of clinical observation, a study was made of blood hemorheology, nail fold microcirculation and among 38 cases of IDA patients. A healthy group was specially set up to make a comparison in blood hemorheology with 38 IDA patients. 38 IDA patients was classified into two groups: group B, 19 IDA patients, with BaZhen decoction treatment; groupC 19 IDA patients, with BaZhen decoction and iron treatment. Treat cycle was two months. Before and after the treatment, all patients are observed the Hb,SI,TIBC,hemorheology and microcirculation .In experimental studies, hypodermic injection of acety pheyl hydrazine (APH) in big mice was employed to prepare anemic models: 10 six-month-olds and 10 eighteen-month olds. Then a contrastive study was made of endothelin-1 (ET-1), calaitonin gene related peptide (CGRP), hemo- rheology, microcirculation on the bottom surface of their feet, thrombase time (TT), prothrombin time (PT), fibrinogen (FIB) content, bleeding and coagulation time as well as pathological changes in healthy Z1 and Z2 mice and anemic M1 and M2 respectively.In the study of clinical literature, an analysis and a synthesis were made of the clinical reseach materials published in recent ten years both in traditional Chinese medicine comcerning cases of blood disase and blood diseases affected by varions kinds of chronic diseases, in order to probe into the interrelation among anemia, blood stasis and bleeding. Result: Clinical observations show the existence of change in hemorheology in patients. There is correlation in group patients and group health: The decrease of WBV,HCT in patients group has significant difference with group health, the inecrease of WBRV,IR,RAI,ET,ESR in patients group has significant difference with group health. This indicates that the changes of the RBC's shape become little and the RBC gathered more and more. Group patient have microcirculation blockages. Most of the sufferers' blood flow slows down; the numbers of capillary loops of nail fold decrease. But the number of shorter, abnormal capillary loops of nail fold increase notably with a varisty of shapes. There is a serious see page of liquid around the nail fold. Red blood cells and blood flow slows down, marked mainly by granule, gathering and intermittence. The blood presents pathological changes such as dark red, dark purple and partial reduction in flow. Moreover, there are 42.1%,32.8% bleeding of microcirculation in group B and group C.After treatment the two group's Hb,SI,TIBC decrease notably (P<0.01 or P<0.05). The SI of group C is rise more markedly than group B. After treatment the targets of hemorheology are all improved, but the improve of WBRV,IR,ET of group C improve better than group B.After treatment the two group's microcirculation are all improved notably, especially in the group B (P<0.01 or P<0.05).The experiment result demonstrates that M₁ and M₂ show obvionsabnomality in hemorheology, bleeding and coagulation time and microcirculation on the sole of the foot compared with normal big mice of the same age. There are obvious blockages in the microcirculation on the sole of the foot, while their bleeding and coagulation time extends markedly (P<0.01 or PO.05). The internal organs of the body such as lung and liver all have damage for lack of blood and pathological changes such as blood stasis and bleeding.From clinical observation and study of the oretical literature, the following has been known. Although blood stasis and bleeding often appear mixed symptom of the illness in many case of anemia. They may affect oneanother, which finally lead deterioration of illness and reduce the effect of treatment.Conclusion: It has been found that anemia exists together with blood stasis and bleeding. BaZhen decoction can improve hemorheology microcirculation of anemia patients. Adopting the means of treatment characterized by the combination of Traditional Chinese Medicine and western medicine, improving the art of treatment based on enriching the blood with due consideration to the adjustment of blood (invigorating the circulation of blood and stopping bleeding), mastering the art of treatment marked by "enriching the blood, without bleeding" and "enriching the blood, stopping bleeding without blood stasis" -all this is of great clinical significance to the treatment of.