The Research Of Alloxan Monohydrate Pyrimidine Inducing The Diabetes Mellitus Rat Mechanism

Objective: Study the ailoxan monohydrate pyrimidine establishing diabetes mellitusfunction mechanism of the small rat models.Method: Choose small 32 of rats from Kunming, which are divided into random twogroups as comparative group and experimental group. The experiment is under thecondition of forbidding the food but water for 12 hours, and injects the alloxanmonohydrate pyrimidine 100 mgs/kgs once for all, while the comparative ones injectthe normal saline. Then, observe the FBG, the carbohydrate tolerance, TG, CH,hepatic glycogen, FSI, GPT, hepatic insulin receptor's protein description.Results: The FBG, TG and CH of The ALX model is in a high side compared with thenormal rats as well as the GPT goes up to some extend. Conclusion: the alloxanmonohydrate pyrimidines cause the blood sugar to increase high falling into it notonly harms pancreatic tissue and bepar tissue and Hepatic function but also restrainthe function of GPT. It is a Hint from here that the increase of the small ratsbloodsugar four caused by the alloxan monohydrate pyrimidine is the comprehensiveeffects that it injures to various organs, which still having the certain distance with theclinical outbreak of the diabetes mellitus of. If the alloxan monohydrate pyrimidine iscapitalized as sugar declining drug, the masculine result would be concerned fromvarious the factors of the sugar declining mechanism: What's more, the feminineeffect can't refuse its sugar declinling function completely. Our experiment effect hintsat the same time that the alloxan monohydrate pyrimidines may become a kind ofdrug that manufactures the liver damage model.Conclusion:1. The alloxan monohydrate pyrimidine causes absolute decrease of the insulin secretquantity through the harm toward the islet of langerhans. Meanwhile. lipidmetabolism caused a mess condition for lacking FSI. Descendens of the serum insulin and the relative sugar, lipid metabolism's change in our experiment solidlyproved that the features of the alloxan monohydrate, pyrimidine small rat models.The animal's model is an animal model that imitates the diabetes mellitus i.2. The alloxan monohydrate pyrimidine make use of the super oxygen free radicalsbroke the islet of langerhans as well as the liver, the index of Hepatic function'sincrease, namely the increase of GPT and the variation of hepar morphologysupported this calculation.3. The alloxan monohydrate pyrimidine damages the liver and influences the sugarand lipid metabolism would result in the application of annimal models. Moreover,to some extend, making use of that animal model to carry on declining the sugarwill result in the effect of the false feminine result.