Study Of The Relationship Between Angiopoietin-2 And Diabetic Vitreous Hemorrhage

Diabetic retinopathy is the commonest cause of blindness in the working age population. Its pathogenesis is increasingly understood with retinal ischemia leading to neovascularisation and increased vascular permeability. The angiopoietins are growth factors that modulate the processes of physiological angiogenesis and pathological neovascularization. It is proposed that angiogenesis play a role in the development of diabetic retinopathy, especially in neovascularisation of proliferative diabetic retinopathy. This study describes the concentrations of angiopoietins-2 in vitreous and plasma of patients undergoing vitrectomy for diabetic vitreous hemorrhage and idiopathic macular hole and detachment of retina caused by high myopia (controls) to investigate the relationship between angiopoietin-2 and diabetic vitreous hemorrhage.Study of the relationship between Angiopoietin-2 levels in plasma and diabetic vitreous hemorrhage.Objective: To investigate the relationship between Angiopoietin-2 levels in plasma and diabetic vitreous hemorrhage. Methods: A total of sixty-one patients with type 2 diabetes mellitus including thirty-one cases of vitreous hemorrhage and thirty cases with non-proliferative diabetic retinopathy as control participate our test. Diagnoses of diabetic retinopathy were made by examination of ocular fundus. Ang-2 in plasma was determined by ELISA. Plasma Ang-2 levels and other factors related to diabetic retinopathy were analyzed by multiple stepwise regressive analysis. Results: Plasma median level of Ang-2 was significantly higher in patients with diabetic vitreous hemorrhage3 176 pg/ml (1944, 3577) than in patients of control group2 301 pg/ml (1638, 2748) (P <0.05) . To define the independent association between plasma Ang-2 level and diabetic vitreous hemorrhage, the multiple Logistic regressive analysis was used. Plasma Ang-2 level related independently and significantly with diabetic vitreoushemorrhage. Conclusion: Ang-2 in plasma is an isolated risk factor of diabetic vitreous hemorrhage.Study of the relationship between angiopoietin-2 levels in vitreous and diabetic vitreous hemorrhageObjective To investigate the relationship between the Ang-2 levels in vitreous and diabetic vitreous hemorrhage. Methods Thirty-one cases with type 2 diabetes mellitus who suffered from vitreous hemorrhage were compared with twenty-five cases of controls. Ang-2 was determined by ELISA in vitreous and plasma. Vitreous Ang-2 level and other factors related to diabetic retinopathy were analyzed by multiple stepwise regressive analysis. Results Vitreous median level of Ang-2 was significantly higher in patients with diabetic vitreous hemorrhage 4 318 pg/ml (2091, 5697) than in patients of control group 274 pg/ml (81, 377) (P<0.05) . To define the independent association between vitreous Ang-2 level and diabetic vitreous hemorrhage, the multiple Logistic regressive analysis was used. Vitreous Ang-2 level related independently and significantly with diabetic vitreous hemorrhage. Conclusion: Ang2 level in vitreous is an isolated risk factor of diabetic vitreous hemorrhage.[Conclusion]K Ang-2 level in vitreous was significantly higher in patients with diabetic vitreous hemorrhage than in control patients. Ang-2 level in vitreous is an isolated risk factor of diabetic vitreous hemorrhage.2n Ang-2 level in plasma was significantly higher in patients with diabetic vitreous hemorrhage than in control group. Ang2 level in plasma is an isolated risk factor of diabetic vitreous hemorrhage.