Long-Term Effect Of Trabeculectomy Combined With Mitomycin C On Congenital Glaucoma

Objective To evaluate the long-term effect of trabeculectomy combined with mitomycin C in the treatment of congenital glaucoma. Methods In a retrospective study, the therapeutic effect of trabeculectomy combined with mitomycin C in 33 cases (51 eyes) of congenital glaucoma was analyzed. Sixteen cases (23 eyes) of congenital glaucoma underwent trabeculectomy alone were also studied as control. Successful surgery were defined as (1) post-operational intraocular pressure (IOP) ≤ 21mmHg, (2)no need of any medication or only topical anti-glaucoma eye drops, and (3) no severe complications. Results The follow-up time was 6 months to 107 months. In patients of primary congenital glaucoma, the success rate surgery of trabeculectomy combined with mitomycin C was 90.47 % with the IOP at the final visit (14.04±5.50 mmHg) significantly (P<0.001) lower than it was before the surgery (32.12±6.59 mmHg ). The success rate of trabeculectomy was 55.55% with the IOP at the final visit (18.86 ± 5.11 mmHg) significantly (P<0.001) lower than it was before the surgery (39.01 ± 7.84 mmHg ). In patients of primary juvenile glaucoma, similar results were observed with the success rate of trabeculectomy conbined with mitomycin C and trabeculectomy was 86.66% and 64.28%, respectively. Survival analysis revealed that the success rate of trabeculectomy conbined with MMC is significantly (P=0.0291) higher thanthat of trabeculectomy. No severe complications could be noticed in both groups. Conclusion Trabeculectomy conbined with mitomycin C is effective and safe enough in the treatment of congenital glaucoma and can be used as the first choice for the surgical management of congenital glaucoma.