The Study Of Major Pharmacodynamics In Compare Jingxin Oral Liquid With Jingxin Grains

Climacteric syndrome means woman during menopause because ovary function fail induced hypothalamus-pituitary- ovary axle out of balance, it is clinical manifestation mainly embody in CNS , spirit , neural symptom, urine secrete and reproduction symptom abnormal.World has already generally acknowledged that it begins since 41 years.This research mainly carry out rat spontaneous locomotor activitias, pentobarbital sodium in low-threshold dosage induced mice sleep time, pentobarbital sodium in threshold dosage induced mice sleep time ,pentylenetetrazole induced seizures in mice after treated with medicine,compare the Jingxin oral liquid with grains in the calm, sleep and the anti-eclampsia aspect to evaluate whether have some difference in efficacy of medicine. Method:After the medicine treatment to assay serum estrogens (E2) content of the unmatured female rat by radioimmunelogic.At the same time ,assay the content of serum follicle hormone (FSH) and luteinizing hormone( LH)in OVX, compare the Jingxin Oral Liquid with grains for the influence of sex hormone whether have some difference.By High-Performance Liquid Chromatography and Electrochemical detection method(HPLC-ECD) measure the content of the norepinephrine(NE),dopamine(DA),5- hydroxytryptamine (5- HT)in brains. Observe the medicine to the influence of monoamine neurotransmitters in brains. Compare Jingxin Oral Liquid with grains whether to have some difference in neurotransmitters that with sleep. Results:1. At dose of 14g crude drug/kg Jingxin Oral Liquid and grains can decrease the number of spontaneous locomotor activitias( p<0.05); increase the rat to fallen asleep rate ( p<0.05) ; prolong the rat sleep time ( p<0.05);Defer the occurrence of the eclampsia ( p<0.05);The Jingxin Oral Liquid and Jingxin grain at dose of 14g crude...