Clinical Study On YIQIHUOXUESUFEI Decoction In Treating Chronic Cough (Lung And Spleen Deficiency Syndrome)

Objective: Further exploration on treating chronic cough with TCM method and its mechanism. Methods:Using YIQIHUOXUESUFEI Decoction (YQHXSFD) which was prepared according to the therapeutic principle of strengthening the body resistance to consolidate the constitution and promoting blood circulation to disslove stasis in treating 40 patients suffering from chronic cough. Results: The clinical investigation shows that YQHXSFD can alleviate symptoms and physical signs of the patients effectively.A total effective rate of 92.5% was shown in YQHXSFD group, which was higher than that of the control group (65.0%),P<0.05. In comparison with the control group,the effect of X-ray was better (P<0.01); the level of serum IgA, IgG, ascended obviously(P<0.01). The level of CDg ascended obviously ,and the level of CD4/CD8 descended obviously(P<0.05).The wave amplitude of pulmonary impedance rheogram and right heart index (HI) increased significantly (P<0.01), which pulmonary arterial pressure (PPA) and pulmonary vascular resistance (PVR) dropped markedly (P<0.01).Conclusion: YQHXSFD might work by means of enhancing the immune system and improving the pulmonary microcirculation to control the type of lung and spleen deficiency syndrome of chronic cough.