Clinical Effects And Changes Of Peripheral Blood Immunology Indicator In The Treatment Of Psoriasis Vulgaris With Curcuma

Objective To observe the clinical effects and changes of CD8+, CD4+, CD25+T cell subpopulations and sIL-2R in the peripheral blood in the treatment of psoriasis vulgaris with curcuma, and to study the role of cell immunity in the pathogenesis of psoriasis and the therapeutic effects of curcuma on psoriasis vulgaris.Methods Thirty psoriasis vulgaris patients selected randomly had been treated with the decoctum of curcuma for eight weeks. PASI scores was used to evaluate the clinical therapeutic effect on patients' lesions. CD8+, CD4+, CD25+T cell subpopulations in the peripheral blood of patients were detected by flow cytometer and double antibody sandwich enzyme-linked immunosorbant assay (ELISA) was used to study the level of sIL-2R in the serum of patients before and after treatment.Results The level of CD8+, CD25+T lymphocytes and sIL-2R were significantly higher and the ratio of CD4+/CD8+ T cells was lower in the peripheral blood in patients than that in control group. PASI scores and the level of CD8+ lymphocytes decreased obviously and the ratio of CD4+/CD8+ T cells increased in patients with psoriasis vulgaris after treatment with curcuma. CD25*T lymphocytes and sIL-2R were correlated strongly with PASI in patients with psoriasis vulgaris and they both decreased significantly after treatment.Conclusions The cell immunity is abnormal in patients with psoriasis. T lymphocyte subsets especially CD8+ T cells may play a important role in the pathogenesis of psoriasis. Psoriasis vulgaris responds significantly to curcuma decoctum which may act on the cell immunity. CD25+T and sIL-2R level in serum is related stongly to PASI scores, which may serve as a value for evaluating the therapeutic result.