Clinical And Experimental Study On Therapy Of Adult Early Non-traumatic Avascular Necrosis Of Femoral Head With Huo Xue Bu Sui Tang Decoction

Objective:To observe the curative effect and side-effect of avascular necrosis of femoral head(ANFH) through clinical observation with Huo Xue Bu Sui Tang Decoction(HXBST) and to investigate the mechanism.Methods:The treated group were treated with HXBST orally.The controlled group were treated with Jian Gu Sheng Pill orally.The difference on curerate,clinical symptoms,laboratory examinations and X-ray markers between the two groups were observed.The changes on liver and renal function were monitored to decide whether HXBST has ill effect. In experment study, We observe the effect of anti-inflammatory, relif of pain, restraining permeation of capillary, regulating metabolism of calcium and phosphor, accelerating the growth of chicken embryo in cuvette.Resultsiln clinical study,the cases with ANFH were treated and observed systematicly for three months. And the results show that HXBST can effectively improve the symptoms of ANFH. The totally effective rate amounts to 81.13% and significantly superior to the control group (P<0.05). The animal experment prove that HXBST has fine effect of anti-inflammatory, relif of pain, restraining permeation of capillary, regulating metabolism of calcium and phosphor, accelerating the growth of chicken embryo in cuvette.ConclusionrThrough the Clinical and Expermental study, The effect of the treated group was better than that of the controll group. The mechanism might be related with its actions of melioration of hemodynamics and mircocirculation, ameliorating the disturbance of metabolism of fattiness, regulating metabolism of calcium and phosphor, accelerating the growth of chicken embryo in cuvette.