Based On The Theory Of "viscers Cause Fear",analysis Of Syndromes And Treatment Of Generalized Anxiety Disorder And Clinical Efficacy Observation Of Dabugan Decoction

Objective: 1.Theoretical research: In a broad sense,"fear" refers to other similar emotional experiences,accompanied by corresponding physical symptoms and abnormal behaviors.This article is referred to as "fear" or "fear syndrome",Is the core clinical manifestation of generalized anxiety disorder.TCM does not have the name of generalized anxiety disorder.Through the analysis of the pathogenic mechanism and clinical manifestations of GAD,this disease belongs to the category of "fear syndrome" in Chinese medicine.Panic is the core clinical manifestation of Generalized anxiety disorder,This article is based on the theory of " Viscera cause fear" in Neijing,It is planned to retrieve and analyze the relevant narratives and therapeutic prescriptions of past dynasties of physicians,Further explore the role of different viscera in the generation and evolution of fear,clarify the development track of the theory of "viscers causing terror",and summarize the ancients' experience in the treatment of fear syndrome.2.Clinical research: Through the association rule analysis of the tutor's prescription drugs for the treatment of this disease,Summarize the instructor's supplementation and improvement of the theory of "viscers causing terror" and the application experience,and observe the clinical efficacy of the extracted core prescriptions,the principles and molecular mechanism of its prescription are analyzed and discussed,in order to provide valuable experience and reference for the treatment of this disease.Methods: 1.Through the retrieval and analysis of ancient and modern literature,the relationship between generalized anxiety disorder and TCM emotional disorders is explored,and the role of different viscera in the generation and evolution of panic emotions is clarified according to the respective physiological functions and characteristics of the viscera.2.Using the "Chinese Medical Dictionary" as the main tool to retrieve the prescriptions used by ancient physicians for the treatment of fear syndromes,under the guidance of the theory of "terrorism caused by viscera",the prescriptions were classified based on the five internal organs,and the groups of representative prescriptions were classified Analyze the prescription mechanism,summarize the medication rules of different viscera that cause panic,break down the theory,and better guide clinical practice.3.Summarize the instructor's perfection and exertion of the theory of "visceral organs causing terror";with the help of SPSS Modeler 18.0 software,analyze the instructor's prescription for treating this disease from liver qi deficiency,extract the core prescription,and summarize the rule of medication.4.Select control drugs,estimate sample content,formulate standards for inclusion and exclusion,grouping principles,and efficacy evaluation criteria,and observe the clinical efficacy of the selected core prescriptions for generalized anxiety disorder.And use network pharmacology and molecular docking technology to explain it from a molecular perspective.Results: 1.Generalized anxiety disorder is closely related to emotional disorders with fear expressions such as "stagnation syndrome","pumping dolphin disease","dirty irritability" and "humiliation" in Chinese medicine.Due to their different physiological functions,the five internal organs play different roles in the generation and evolution of panic: the mind hides the spirit,lack of qi and blood,and the mind is lost;turbid evil invades,and the mind is restless,which can cause endogenous fear.The liver hides the soul.If the liver and gallbladder are weak,the essence and blood are insufficient,or the external evil invades,and the soul is uneasy,it will cause panic.The spleen hides its meaning.If the spleen is insufficiency,dereliction of duty,lack of source of qi and blood,and unhealthy spleen,you will be worried and fearful.The kidney stores the essence,which is fear of the kidney,and the kidney disease fears endogenous.The lungs hold the soul,and lung injury is the main qi function.The viscera is unbalanced,and fear is prone to occur.2.Searching the "Chinese Medical Dictionary" with keywords such as "fear",and retrieved a total of 749 relevant prescriptions.High-frequency prescriptions with more than 7 occurrences involved 49 categories,1482 pathogenesis.Representative prescriptions for treatment from the heart include Miaoxiangsan,Siwu Anshen Decoction,Zhusha Anshen Pill,Jiawei Dingzhi Pills,etc.;representative prescriptions for treatment from the liver(gallbladder)include Shiwei Wendan Decoction,Renshu San,and Tonic Danfangfeng Decoction,Xieqing Pills,etc.;the representative prescription for treating the spleen(stomach)is Guipi Decoction,Buzhong Yiqi Decoction,Poria Yinzi,etc.;the representative prescriptions for treating the kidney include Gorgon Pills,Sanren Wuzi Pills,etc.;the representative prescriptions for treating the lungs include Xingshen San.3.On the basis of a full understanding and grasp of the classic medical books,the instructor put the theory of "Deficiency of Liver Qi and Fear" in the "Internal Classics" into practice,forming the diagnosis and treatment characteristics of treating general anxiety from the theory of deficiency of liver Qi,and further improving The theory of "fear caused by viscera".Using SPSS Modeler 18.0 software to analyze the association rules of the instructor's prescriptions for treating this disease from the theory of liver qi deficiency,it was found that the Dabugan Decoction of "Fuxing Jue" is the core prescription for the treatment of this syndrome,and the "Treatise on Febrile Diseases" Chaihu Guizhi Dried Ginger Decoction is a commonly used prescription for the treatment of this type of syndrome;the drugs that are often used in combination with emotion regulation include Morinda officinalis,Baiwei,Platycodon grandiflorum,oyster,Polygala,Muxiang and so on.4.Clinical studies have shown that Dabugan Decoction can shorten the time required for western medicine to take effect and maintain the stability of the curative effect.Compared with the use of Western medicine alone,the combined use of Dabugan Decoction can significantly alleviate the anxiety symptoms of subjects and improve patients' anxiety Quality of Life.Network pharmacology research results show that Dabugan Decoction can exert therapeutic effects by acting on multiple key targets and intervening in multiple pathways;the molecular docking results also show that the effective components of Dabugan Decoction are more comparable to multiple core targets of the disease.Strong binding ability.Conclusion: The theory of "Terror caused by viscera" in Neijing has clarified in detail that the malfunction of viscera is the root cause of panic.Later physicians have continuously improved this theory in the long-term clinical practice and accumulated a large number of effective prescriptions.The purpose of the teacher's "Internal Classic",which has not been published before,has perfected the "organs causing terror".Through the study of the classics,the medication complies with the meaning of The theory of“deficiency of qi and fear” is put into clinical practice.The Dabugan Decoction of "Fu Xing Jue",Chaihu Guizhi Ganjiang Decoction of "Treatise on Febrile Diseases" and other prescriptions are used to treat fear syndrome,and have achieved good curative effect;It is proved that Dabugan Decoction is an effective prescription for treating generalized anxiety and liver-qi deficiency syndrome,and modern technical methods such as network pharmacology and molecular docking have also confirmed this point.