The Study Of PET Functional Imaging Of AD'Brain After Treatment Of Senmen Acupuncture

Objective:Alzheimer's disease (AD) is a disease of the old, which is also named senile dementia.it is mainly demonstrateted the symptoms of cognitive handicap of progressive hypomnes ia occurred at the presensium or senectitude, which accompanied by psychological and dystropic neurodegene rative symptoms. Its characteri clinical manifestations is a serious decline in learning and memory function, arialytical judgement capacity of a recession, emotional changes and dystropy, which has seriously affected the daily life and rusult in decline of the quality of patient's life.The pathogenesis of AD is so complicated because Many signaling molecules have taken part in the process of it.How to make clear The pathogenesis of AD is a most difficult problem the doctors and medical science workers should handle.The traditional chinese medcine has special ways to prevent or treat senile diseases, and it has shown good curative effect on AD'treatment. The traditional chinese medicine treat AD with chinese medcine and acupuncture while senmen point always been used as a effective point during the AD'therapy.But its mechanism of action is not very clear.So the reseach of it is very meanful.We apply the 18F-PET functional image to study the metergasis feature of AD'brain which treated by puncturing senmen ponit, and analysis different point's various action on the various emcephalic regions. From this, we can choose effective acupoints of AD'treatment, And offer an experimental basement of standard prescription of AD's treatment.Methods:SD rats were randomly divided into 3 groups:the normal group, puremodle group and senmen group, the puremodle group were made by damage of the basal ganglia and injection of D-galactose in belly and IBO in nucleon. After the modles were made, We used Y maze to test the changes in learning and memory abilities in each group, research their differents refle-ctions.Senmen group has an examination on brain with 18F-PET functional image treatment during needling.and after twenty-day' acupuncture treatment only in senmen group, three groups were send for 18F-PET functional imaging againResults:1,the results of Y mase examine:before the treatment, Comparing the normal group to puremodle group, the total reaction time of puremodle group rats was longer than the former, there was significance in the two groups (P＜0.05); compared with the puremodle group, the total reaction time of senmen group rats was shorter than the former, there was no significant difference (P＞0.05); after the treatment, Compared with the normal group, the total reaction time of normalgroup rats was shorte than the former, there was significance in the two groups (P＜0.01); and Compared with the puremodle group, the total reaction time of senmen group rats was shorter thanthe former, there was significance in the two groups(P＜0.01).2,PET functional imaging:①the immediatelly effect of senmen acupuncture:Compared with the puremodle group, there was high reactive site in corpus striatum of brains of senmen group.②the curative effect of senmen acupuncture:Compared with the puremodle group, there was various high reactive site in corpus striatum of brains of senmen group, inclnding left Frontal Lobe:Motor Cortex, left Corpus Callosum, Left Limbic System:Septal Area, Leftriatum, Left ocampus, L Third Ventricle, L Frontal Lobe:Orbital Cortex, L Frontal Lobe rontal Asso-ation Cortex.Conclusions:based on the the results of Y mase examine, we can conclude senmen point can improve the ability of learning and memory of AD rats. From the results of the PET imaging, we found senmen point activate several regions of the brain and it improve the function Of the AD's brain with various ways and targets. comparing the PET imaging immediately and after treatment of the brain of senmen group, much diffrences could be found, after treatment, much more points in the brain were be activated, and the function of these encephalic region were so different, so, it indicated that needling Senmen point can activate several points in the brain and improve their functions, but this function need one course of treatment at least, while, the therapeutic effect could last some time. This experiment also showed acupunture have curative effect on many diseases by multi-target, multi-channel, multi-strata. The experiment offered laboratory evidence on AD, treatment by acupuncture, meanwhile,it also establish the foundament to better acupuncture treatment of AD.