| OBJECTIVE: Observe and analyze the pathological and physiological state of menstrual headache which is made by the experimental method. At the same time combine the treatment to the advantage of TCM which regulates menses and stops pain. Discuss the pathogenic factors and treatment of herbs. METHOD: Divided SD rats aged at 3-4months into seven groups, such as group of contrast, Nitroglycerin, Estradiol, Estradiol with methyl testosterone, Estradiol with Aspirin model, Estradiol with Jingqing Capsule with great dose and Estradiol with Jingqing Capsule with little dose. Through setting up the files of estrous cycle individually and make the models during the estrous period, observe if subcutaneous injection of estradiol benzoate can effect the experimental rats' following indexes such as the index of vaginal keratinocyte, prostaglandin E2 of pallium and plasm, calcitonin-gene-related peptide(CGRP) of plasm, organic modality of endocranium, expression of Substance P, nitricoxide synthase and c-fos of trigeminal Nucleus, and testify the success of Estradiol model by comparing with the positive Nitroglycerin model. Explore the possible tampering function of Jingqing Capsule by the evaluation on Estradiol, progestin, testosterone and prolactin. RESULTS: Exogenetic estradiol can lift the index of vaginal keratinocyte and increase prostaglandin E2 of pallium and plasm, calcitonin-gene-related peptide(CGRP) of plasm; strengthen expression of Substance P, nitricoxide synthase and c-fos of trigeminal Nucleus, and cause hemangiectasis of endocranium, obvious circumvascular inflammatory edema and circumvascular hyperplastic cells. All the pathological change is the same as the Nitroglycerin model group. Jingqing Capsule can reduce the index of vaginal keratinocyte, serous estradiol, progesterone, prolactin, prostaglandin E2 of pallium and plasm, calcitonin-gene-related peptide(CGRP) of plasm, restore expression of the substance P, nitricoxide...
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